Use of Botulinum Toxin in Urologic Diseases

Urology
Christopher J Chermansky, Michael B Chancellor

Abstract

OnabotulinumtoxinA (onaBoNTA) is approved by the US Food and Drug Administration for the treatment of urinary incontinence due to neurogenic detrusor overactivity and for the treatment of refractory overactive bladder. As a treatment for benign prostatic hyperplasia, onaBoNTA showed no difference over placebo in recently published studies. In contrast, treating interstitial cystitis/bladder pain syndrome with onaBoNTA has shown efficacy, and the current American Urological Association guideline for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome lists onaBoNTA as fourth-line treatment. This comprehensive review will present all studied applications of onaBoNTA within the lower urinary tract.

References

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May 8, 2008·Nature Clinical Practice. Urology·Michael B ChancellorK Roger Aoki
May 21, 2008·Nature Reviews. Neuroscience·Clare J FowlerWilliam C de Groat
Feb 8, 2013·Neurourology and Urodynamics·Eric RovnerCornelia Haag-Molkenteller
Jul 31, 2013·Neurology·Michael B ChancellorChristopher R Chapple
Aug 29, 2013·Female Pelvic Medicine & Reconstructive Surgery·Amos AdelowoEman Elkadry
Jan 28, 2015·The Journal of Urology·Philip M HannoUNKNOWN American Urological Association
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