PMID: 9535297Apr 16, 1998Paper

Use of botulinum toxin injection in 17 children with spastic cerebral palsy

Pediatric Neurology
V Wong

Abstract

The use of botulinum toxin was studied in 17 children with spastic cerebral palsy to determine its efficacy and tolerability. Eleven ambulatory and 6 nonambulatory patients were included. All children were undergoing a physiotherapy program with monitoring of their baseline states for 3 months before botulinum toxin injection. The effect was evident within 72 hours. The peak effect was noticed by 1 to 2 weeks in the majority; the effect lasted for 3 to 10 months. All children experienced decreased spasticity scores. Their functional status improved, with three nonambulatory children becoming ambulatory with assistance and five children with assisted ambulation becoming more independently ambulatory. Measurement of joint motion showed improvement in the range of motion as compared with baseline. Video analysis of the functional state in the nonambulatory or gait in the ambulatory children revealed improvement in all. The functional status of rising from the sitting position or standing demonstrated improvement. None of the children had any untoward side effects except mild transient pain at the injection site. This study demonstrated botulinum toxin is useful as an adjunctive therapy in ameliorating spasticity in children with c...Continue Reading

References

Sep 24, 1976·Science·I KaoD L Price
Oct 1, 1990·Annals of Neurology·B J SnowD B Calne
Jan 1, 1987·Pediatric Neuroscience·W J PeacockB Berman
Nov 1, 1985·Journal of Pediatric Orthopedics·R L SilverJ de la Garza
Jan 1, 1973·The Journal of Bone and Joint Surgery. American Volume·M M HofferC Bonnett
Jan 8, 1981·The New England Journal of Medicine·R R Young, P J Delwaide
Sep 1, 1994·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·P T Castiglia
Jun 1, 1994·Pediatric Neurology·R Calderon-GonzalezE Mino-Arango
Jul 1, 1993·Journal of Pediatric Orthopedics·L A KomanT Mulvaney
Oct 1, 1995·Neuropediatrics·M Denislic, D Meh
May 1, 1996·Archives of Physical Medicine and Rehabilitation·J L Gooch, T V Sandell

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Citations

Feb 20, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R N Boyd, R M Hays
Feb 20, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S C LoveP J Chauvel
Oct 21, 2006·Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association·H M DumasM A Fragala
Oct 21, 2006·Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association·Maria A FragalaHelene M Dumas
Feb 7, 2003·The Clinical Journal of Pain·Christopher F O'Brien
Mar 2, 2006·Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association·Hilda Mulligan, Erin Wilmshurst
Sep 19, 2007·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Lidija DimitrijevićIrena Janković
Mar 25, 2009·Journal of Children's Orthopaedics·Aviva Fattal-ValevskiShlomo Hayek
Nov 4, 2008·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Guy MolenaersKaat Desloovere
Sep 23, 2008·Pediatric Neurology·Beth E Crowner, Brad A Racette
Dec 27, 2005·Pediatric Neurology·Alberto VerrottiPaola Iannetti
Oct 29, 2003·Physical Medicine and Rehabilitation Clinics of North America·Deborah Gaebler-Spira, Gadi Revivo
Dec 20, 2005·Developmental Medicine and Child Neurology·Vanessa A B ScholtesGustaaf J Lankhorst
May 17, 2014·Journal of Biomechanics·Ryan PotterStavros Thomopoulos
Dec 13, 2006·Journal of Child Neurology·Ozlem ElHaluk Berk
Feb 28, 2001·Journal of Child Neurology·E M Goldstein
Apr 16, 2002·Journal of Child Neurology·Virginia WongPatsy Sit
Jun 29, 2002·Journal of Child Neurology·Aviva Fattal-ValevskiShlomo Hayek
Aug 12, 2006·Journal of Child Neurology·Daniel L HurstMargie E Lance-Fish
Sep 24, 2004·American Journal of Physical Medicine & Rehabilitation·Li-Rong LeeYing-Hung Liu
Apr 16, 2002·American Journal of Physical Medicine & Rehabilitation·Han-Cheng WangShih-Min Lou
Oct 9, 2019·The Cochrane Database of Systematic Reviews·Francesco C BlumettiJosé A Pinto
Mar 4, 2000·American Journal of Physical Medicine & Rehabilitation·A FriedmanC Daffner
Oct 4, 2002·American Journal of Physical Medicine & Rehabilitation·Moon Suk BangSang-Jun Kim
Jul 20, 2002·American Journal of Physical Medicine & Rehabilitation·Ta-Shen KuanChang-Zern Hong
Apr 3, 2009·The Journal of Bone and Joint Surgery. American Volume·H Mike KimStavros Thomopoulos
Mar 17, 2004·American Journal of Physical Medicine & Rehabilitation·Robert SavareseScott R Millis
May 18, 2004·Lancet·L Andrew KomanJeffrey S Shilt

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