Abstract
First-generation prosthetic heart valves commonly caused sufficient red blood cell (RBC) injury to induce hemolytic anemia. Although multiple studies have shown that new-generation valves are not associated with anemia, the extent to which these valves are injurious to RBCs is not known, because RBC survival not has not been measured in these subjects. Using a technique that uses breath carbon monoxide (CO) to quantify RBC turnover, this study measured RBC life span in 38 subjects with normally functioning, new-generation valves. Erythrocyte survival averaged 98.8 +/- 23 and 103 +/- 15 days, respectively, in 20 subjects with mechanical valves and 18 subjects with bioprosthetic valves (p >0.05). However, these life spans were significantly (p <0.01) less than those of healthy subjects (122 +/- 23 days) and a group of elderly subjects with osteoarthritis (128 +/- 26 days). The mean hemoglobin concentrations of the 2 groups of valve patients were within normal limits. In conclusion, new-generation heart valves commonly are associated with a small degree of hemolysis that is compensated for by increased RBC production.
References
Jan 1, 1977·British Journal of Haematology·I CavillA Jacobs
Jan 1, 1977·British Journal of Haematology·C RickettsA Jacobs
May 1, 1970·The Journal of Clinical Investigation·S A LandawR Schmid
Jul 25, 2003·The Journal of Laboratory and Clinical Medicine·Julie K FurneMichael D Levitt
Jul 1, 1961·British Journal of Haematology·J G EERNISSE, J van ROOD
Mar 30, 2004·Diabetes Care·Mark A VirtueMichael D Levitt
May 26, 2004·International Journal of Cardiology·Michael SuedkampUwe Mehlhorn
May 28, 2004·American Journal of Hematology·Mark A VirtueMichael D Levitt
Jun 11, 2004·Chest·Toshika OkumiyaTetsuro Sugiura
Citations
Mar 25, 2009·International Journal of Hematology·Patrizia CaprariMaria Cristina Martorana
Apr 23, 2009·Cardiology in Review·Yaron ShapiraAlex Sagie
Jun 27, 2013·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Robert S Franco
Aug 13, 2008·Blood·Robert M CohenClinton H Joiner
Jun 16, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Sheeja M Krishnan, Narendra M Dixit
Nov 26, 2008·American Journal of Hematology·Robert S Franco
Jul 20, 2013·Artificial Organs·Vance G NielsenM Cristina Smith
Jun 14, 2016·BioMed Research International·Yong-Jian MaLei Wang
Jul 1, 2016·International Heart Journal·Tetsuro SugiuraYoshihisa Matsumura
Aug 11, 2016·Journal of Breath Research·Yong-Jian MaKun-Mei Ji
Feb 6, 2018·Journal of Breath Research·Hou-De ZhangKun-Mei Ji
Jul 23, 2020·European Heart Journal Supplements : Journal of the European Society of Cardiology·Andrea ŠirákováViktor Kočka
Dec 21, 2019·Scientific Reports·James P BuerckEdgar A O'Rear
Jan 10, 2021·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·James P BuerckEdgar A O'Rear
Jul 16, 2021·American Journal of Hematology·Lei YeFengkui Zhang