Use of breath carbon monoxide to measure the influence of prosthetic heart valves on erythrocyte survival

The American Journal of Cardiology
Benjamin L MitlyngMichael D Levitt

Abstract

First-generation prosthetic heart valves commonly caused sufficient red blood cell (RBC) injury to induce hemolytic anemia. Although multiple studies have shown that new-generation valves are not associated with anemia, the extent to which these valves are injurious to RBCs is not known, because RBC survival not has not been measured in these subjects. Using a technique that uses breath carbon monoxide (CO) to quantify RBC turnover, this study measured RBC life span in 38 subjects with normally functioning, new-generation valves. Erythrocyte survival averaged 98.8 +/- 23 and 103 +/- 15 days, respectively, in 20 subjects with mechanical valves and 18 subjects with bioprosthetic valves (p >0.05). However, these life spans were significantly (p <0.01) less than those of healthy subjects (122 +/- 23 days) and a group of elderly subjects with osteoarthritis (128 +/- 26 days). The mean hemoglobin concentrations of the 2 groups of valve patients were within normal limits. In conclusion, new-generation heart valves commonly are associated with a small degree of hemolysis that is compensated for by increased RBC production.

References

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Citations

Apr 23, 2009·Cardiology in Review·Yaron ShapiraAlex Sagie
Jun 27, 2013·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Robert S Franco
Jun 16, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Sheeja M Krishnan, Narendra M Dixit
Nov 26, 2008·American Journal of Hematology·Robert S Franco
Jun 14, 2016·BioMed Research International·Yong-Jian MaLei Wang
Jul 1, 2016·International Heart Journal·Tetsuro SugiuraYoshihisa Matsumura
Jul 23, 2020·European Heart Journal Supplements : Journal of the European Society of Cardiology·Andrea ŠirákováViktor Kočka
Jan 10, 2021·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·James P BuerckEdgar A O'Rear

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