Use of buspirone and fluoxetine for breathing problems in Rett syndrome

Pediatric Neurology
Sarenur GökbenGül Serdaroğlu

Abstract

Rett syndrome is a severe neurodevelopmental disease with a prevalence of 0.88 per 10,000 girls aged 5-18 years, and is often caused by mutations in methyl-cytosine-phosphate-guanine (CpG)-binding protein 2. Disorder of respiratory control is a prominent feature of Rett syndrome. Brainstem serotoninergic neurons are known to play an important role in the arrangement of breathing rhythm and pattern. We present a patient whose severe hyperventilation and apneic attacks resolved with the concomitant treatment of fluoxetine and buspirone. To our knowledge, we describe the first patient with Rett syndrome to receive fluoxetine for respiratory problems.

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Citations

Apr 11, 2015·Medical Hypotheses·Shih-Jen Tsai
Jul 2, 2016·Pediatric Neurology·Aleksandra DjukicSolomon L Moshé
Oct 5, 2013·Journal of Applied Physiology·Erica S LevittJohn M Bissonnette
Dec 5, 2019·Developmental Medicine and Child Neurology·Bradley C ClarkAleksandra Djukic
May 4, 2017·Journal of Neurodevelopmental Disorders·Jessica MackayHelen Leonard
Feb 6, 2020·Journal of Autism and Developmental Disorders·Mohan GomathiVellingiri Balachandar
Mar 12, 2020·Journal of Medical Genetics·Michael Sean CarrollDebra E Weese-Mayer
Sep 29, 2020·BMJ Paediatrics Open·Cary FuTimothy Benke
Apr 25, 2021·Seminars in Pediatric Neurology·Autumn S Ivy, S M Standridge

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