Use of CA 125 monoclonal antibody to monitor patients with ovarian cancer.

Gynecologic Oncology
S KudlacekM Micksche

Abstract

The monoclonal antibody (mAb) OC 125 reacts with an antigen on human ovarian carcinoma (OVCA) cells that is also shed into the body fluids and can be detected in patients' sera and/or ascites with a radioimmunometric assay. For the present study, serum CA 125 levels of patients (n = 36) with different stages of OVCA were investigated. Serum levels seem to correlate with tumor burden. In stages I and II (n = 12), 33% of patients were CA 125 positive, whereas 70% of stage III and IV patients (n = 24) were CA 125 positive. Mean serum levels were in 93 U/ml (stages I, II) and 279 U/ml (stages III, IV). CA 125 levels in ascites and in pleural effusions were manyfold higher than serum levels of the same patients (P less than 0.0001). Immunohistochemical investigations of CA 125 in different ovarian tumors (n = 91) revealed that 85% of malignant and 75% of borderline serous cystadenocarcinomas had detectable CA 125 surface expression. Furthermore, 71% of benign tumors showed the CA 125 epitope, whereas mucinous tumors were negative for this marker. One of six ovarian cancer cell lines was CA 125 positive, whereas in 6 of 11 patients, ascites-derived ovarian cancer cells (fresh and gradient isolated) were positive for this marker. The ...Continue Reading

References

Feb 14, 1985·The New England Journal of Medicine·G S RichardsonJ H Nelson
Feb 1, 1986·American Journal of Obstetrics and Gynecology·D B AtackL Levin
Feb 21, 1985·The New England Journal of Medicine·G S RichardsonJ H Nelson
Apr 15, 1984·American Journal of Obstetrics and Gynecology·J M NiloffR C Bast
Oct 13, 1983·The New England Journal of Medicine·R C BastR C Knapp
Nov 1, 1981·The Journal of Clinical Investigation·R C BastR C Knapp
Jun 1, 1982·Gynecologic Oncology·W S RobertsP J DiSaia

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Citations

Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C. W. BurgerP. Kenemans
Jan 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H M OgmundsdottirS Jonasdóttir
May 1, 1995·Cancer Treatment Reviews·M K TuxenP Dombernowsky
Jul 13, 2018·Expert Opinion on Therapeutic Targets·Abhijit AithalSurinder K Batra
Jun 6, 2015·Journal of Menopausal Medicine·Jung-Woo Park, Jong Woon Bae

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