Use of calcitriol to maintain postpartum blood calcium and improve immune function in dairy cows

Journal of Dairy Science
A Vieira-NetoJ E P Santos

Abstract

Our objectives were to determine the effects of an injectable formulation of calcitriol on mineral metabolism and immune function in postpartum Holstein cows that received an acidogenic diet prepartum to minimize hypocalcemia. In experiment 1, cows within 6 h of calving received calcitriol (0, 200, or 300 μg) to determine the dose needed to increase plasma concentrations of Ca; 300 μg was sufficient to sustain Ca for at least 3 d. In experiment 2, multiparous cows were assigned randomly to receive only vehicle (control, n = 25) or 300 μg of calcitriol (n = 25) subcutaneously within the first 6 h after calving. Blood was sampled before treatment and 12 h later, then daily until 15 d in milk (DIM), and analyzed for concentrations of ionized Ca (iCa), total Ca (tCa), total Mg (tMg), and total P (tP), metabolites, and hormones. Urine was sampled in the first 7 DIM and analyzed for concentrations of tCa, tMg, and creatinine. Neutrophil function was evaluated in the first week postpartum. Dry matter intake and production performance were evaluated for the first 36 DIM. Calcitriol administration increased concentrations of calcitriol in plasma within 12 h of application from 51 to 427 pg/mL, which returned to baseline within 5 d. Conc...Continue Reading

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Citations

Jul 25, 2019·Animal : an International Journal of Animal Bioscience·L E Hernández-CastellanoR M Bruckmaier
Nov 7, 2017·Journal of Animal Science·R ÖzçelikL E Hernández-Castellano
Dec 18, 2021·Veterinary Medicine and Science·Morteza HassanabadiHesam A Seifi

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