Use of calcium-based demineralized bone matrix/allograft for nonunions and posttraumatic reconstruction of the appendicular skeleton: preliminary results and complications

The Journal of Trauma
Bruce H ZiranSteve J Morgan

Abstract

There are numerous autograft alternatives promoted. Although most have laboratory or animal data, few have evaluations of clinical performance. We performed an evaluation of a new calcium sulfate-demineralized bone matrix/Allomatrix in the treatment of nonunions. A consecutive series of patients requiring bone grafting for atrophic/avascular nonunions were retrospectively studied. Patients were monitored for healing and adverse effects, which included local or systemic reactions, wound problems, infection, and any secondary surgery caused by graft complications. Over half of the patients (51%) developed postoperative drainage. Of the 41 patients, 13 (32%) had drainage that required surgical intervention and 14 (34%) developed a deep infection. Eleven patients with deep infections also required surgical treatment of drainage. Also, 19 (46%) patients did not heal and required secondary surgical intervention. Using chi it was found that there were correlations between infection and a history of previously treated infection (p < 0.007), as well as wound drainage (p < 0.001). Failure of treatment correlated to the presence of a postoperative infection (p < 0.001). Other analyses were not performed because of the small sample size, w...Continue Reading

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Citations

Aug 2, 2007·International Orthopaedics·Gavin B Bishop, Thomas A Einhorn
Oct 22, 2009·International Orthopaedics·Ippokratis PountosPeter V Giannoudis
Dec 17, 2009·Journal of Trauma Management & Outcomes·Oliver PieskeStefan Piltz
May 27, 2010·Indian Journal of Pharmaceutical Sciences·A AnandH Gupta
Mar 10, 2010·Journal of Orthopaedic Trauma·Ramsey C KinneyTimothy Ganey
Aug 12, 2014·Expert Opinion on Drug Delivery·Vuk Uskoković, Tejal A Desai
Jan 8, 2013·Expert Opinion on Drug Delivery·Otto S KluinDaniëlle Neut
Nov 26, 2009·The Orthopedic Clinics of North America·James T Marino, Bruce H Ziran
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Vuk Uskoković
Nov 26, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mark V Thomas, David A Puleo
Aug 3, 2016·The Bone & Joint Journal·S M ShielsJ C Wenke
Dec 17, 2016·Journal of Orthopaedic Trauma·Ethan S KrellSheldon S Lin
Sep 25, 2017·Journal of Orthopaedic Trauma·Theodoros H Tosounidis, Peter V Giannoudis
Mar 10, 2010·Journal of Orthopaedic Trauma·Murray J S Beuerlein, Michael D McKee
Mar 11, 2018·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Philipp StörmannChristoph Nau
Aug 29, 2012·ANZ Journal of Surgery·Luke James Johnson, Mark Clayer
Nov 14, 2013·The Journal of Craniofacial Surgery·Shima TavakolSeyed Mahdi Rezayat Sorkhabadi
Sep 10, 2019·Orthopaedic Surgery·Hao ZhangYong-Cheng Hu
Feb 16, 2016·Regenerative Medicine·Melvin C MakhniFrancis Y Lee
Jun 15, 2018·Journal of Tissue Engineering·Gabriel Fernandez de GradoDamien Offner

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