Use of calcium channel blockers (CCB) for tocolysis in France and abroad

Journal de gynécologie, obstétrique et biologie de la reproduction
O ParantB Guyard-Boileau

Abstract

Calcium channel blockers (CCB) are routinely off-label used for tocolysis. The purpose of this study is to establish an inventory of the use of CCB for tocolysis in France and abroad. Four complementary approaches were performed: (i) a literature review of clinical practice and guidelines of scientific societies; (ii) a national declarative practice survey among French tertiary care centers; (iii) a regional declarative practice survey among all maternities of the Midi-Pyrénées Perinatal Network (MATERMIP); (iv) an evaluation of outpatient tocolysis prescription, analyzing the departmental database EFEMERIS in order to examine drug prescribing during pregnancy. CCB appear to be currently used as first-line, initial tocolysis, in the majority of French maternity hospitals (82.5% of tertiary care centers). Oral Nifedipine is the predominant regimen (86%). CCB utilization rates appear higher than those reported in 2005 in the EVAPRIMA study. Beta-agonists appear rarely prescribed in 1st line (poor maternal tolerance) and even abandoned by many institutions (75% of tertiary care centers). Using a maintenance tocolysis (usually by long-acting CCB) seems to vary depending on the hospitals. It would be prescribed in more than 50% of c...Continue Reading

References

Apr 20, 2004·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Colleen-M Cook, Michael J Peek
Jul 2, 2008·Obstetrics and Gynecology·Maria A MorganJay Schulkin
Nov 28, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·O ParantUNKNOWN EVAPRIMA Group
Apr 15, 2009·European Journal of Clinical Pharmacology·I LacroixC Damase-Michel
Jul 16, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·C Le RayUNKNOWN groupe EVAPRIMA
Jan 3, 2013·JAMA : the Journal of the American Medical Association·Carolien RoosUNKNOWN APOSTEL-II Study Group

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Citations

Oct 3, 2019·Archives of Gynecology and Obstetrics·Patrick StelzlWerner Rath
Feb 25, 2019·Thérapie·Justine BeneventChristine Damase-Michel
Sep 26, 2017·Seminars in Perinatology·Isabelle DehaeneUNKNOWN from the International Spontaneous Preterm birth Young Investigators group (I-SPY)

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