PMID: 11345308May 10, 2001Paper

Use of carboplatin for treatment of dogs with malignant melanoma: 27 cases (1989-2000)

Journal of the American Veterinary Medical Association
K M RassnickAntony S Moore

Abstract

To evaluate response rate and duration of malignant melanomas in dogs treated with carboplatin. Retrospective study. 27 client-owned dogs with spontaneously occurring measurable malignant melanomas. Records of dogs with melanomas treated with carboplatin from October 1989 to June 2000 were reviewed. Carboplatin was administered IV at doses of 300 or 350 mg/m2 of body surface area. Response to treatment and evidence of drug toxicity were determined. Response to treatment could be evaluated in 25 dogs. Of those, overall response rate was 28%. One dog had a complete response, 6 (24%) dogs had a partial response (> 50% reduction in tumor burden). Median duration of partial response was 165 days. Eighteen dogs had stable disease (n = 9; 36%) or progressive disease (9; 36%). Response to treatment was significantly associated with carboplatin dose on a milligram per kilogram basis (15.1 mg/kg 16.9 mg/lb] of body weight vs 12.6 mg/kg [5.7 mg/lb]). Evidence of gastrointestinal toxicosis could be assessed in 27 dogs. Mean body weight of 5 dogs that developed gastrointestinal toxicosis was significantly less than that of 22 dogs without gastrointestinal toxicosis (9.9 kg [21.8 lb] vs 19.3 kg [42.5 lb]). Carboplatin had activity against ma...Continue Reading

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