Use of celecoxib correlates with increased relative risk of acute pancreatitis: a case-control study in Taiwan

The American Journal of Gastroenterology
Shih-Chang HungHung-Chang Hung

Abstract

This study evaluated whether there is an association between the use of celecoxib and acute pancreatitis in Taiwan. We conducted a case-control study using the database of the Taiwan National Health Insurance Program. The participants comprised 5,095 subjects, aged 20-84 years, with a first admission episode of acute pancreatitis from 2000 to 2011 as the cases and 20,380 randomly selected sex-matched and age-matched subjects without acute pancreatitis as the controls. The absence of celecoxib prescription was defined as "never used." Current use of celecoxib was defined as subjects who had received at least one prescription for celecoxib within 3 days before diagnosis with acute pancreatitis. A multivariate unconditional logistic regression model was used to calculate the odds ratio (OR) and 95% confidence interval (CI) for acute pancreatitis associated with the use of celecoxib. Compared with subjects who never used celecoxib, the adjusted OR of acute pancreatitis was 5.62 in subjects with current use of celecoxib (95% CI=3.33-9.46). The current use of celecoxib is associated with an increased risk of acute pancreatitis.

References

Jul 16, 1994·BMJ : British Medical Journal·R Gillon
Mar 1, 2000·Archives of Internal Medicine·R Carrillo-Jimenez, M Nurnberger
Apr 15, 2000·Annals of Internal Medicine·A M BaciewiczT J King
Jul 24, 2002·European Journal of Clinical Pharmacology·Kerstin B BlomgrenBengt-Erik Wiholm
Jan 7, 2003·Internal Medicine Journal·G Nind, W Selby
Jul 3, 2004·BMJ : British Medical Journal·Munir PirmohamedAlasdair M Breckenridge
Jul 3, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R PezzilliUNKNOWN ProInf-AISP Study Group
Oct 11, 2007·Gastroentérologie Clinique Et Biologique·Didier MennecierOlivier Farret
Feb 6, 2009·Drugs·Marco Lazzaroni, Gabriele Bianchi Porro
Mar 14, 2009·Current Gastroenterology Reports·Albert B LowenfelsThomas Sullivan
Sep 14, 2011·Annals of Family Medicine·Laura PlantingaUNKNOWN CDC CKD Surveillance Team
Sep 21, 2011·Journal of Gastroenterology and Hepatology·Kuan-Fu LiaoWen-Chi Chen
Oct 18, 2011·BMC Gastroenterology·Shih-Chang HungWen-Chi Chen
Feb 9, 2012·Current Gastroenterology Reports·Claudia NitscheJulia Mayerle
Jul 21, 2012·Cutaneous and Ocular Toxicology·Bengu Gerceker TurkGunseli Ozturk
Jul 31, 2013·The American Journal of Gastroenterology·Scott TennerUNKNOWN American College of Gastroenterology
Jan 29, 2014·Wiener medizinische Wochenschrift·Heinz F Hammer
Aug 2, 2014·Pancreas·Shin HamadaUNKNOWN Research Committee of Intractable Diseases of the Pancreas
Sep 26, 2014·The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology·Ali Tüzün Ince, Birol Baysal
Dec 4, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Rakesh PremkumarJohn A Windsor
Dec 4, 2014·World Journal of Gastroenterology : WJG·Scott Tenner

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Citations

Apr 1, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Shih-Chang HungChih-Hsueh Lin
May 6, 2017·BioMedicine·Kuan-Fu LiaoShih-Wei Lai
Mar 16, 2017·PloS One·Fan-Gen HsuKuang-Hsi Chang
Mar 17, 2017·Journal of Clinical Pharmacology·Chih-Ming LinShih-Wei Lai
Apr 24, 2017·European Journal of Clinical Pharmacology·Hsien-Feng LinShih-Wei Lai
Mar 15, 2018·The American Journal of Gastroenterology·Neville D YeomansSteven E Nissen
Jun 21, 2018·The American Journal of Gastroenterology·Shih-Wei LaiShih-Chang Hung
Mar 1, 2017·European Journal of Hospital Pharmacy. Science and Practice·Shih-Wei LaiKuan-Fu Liao

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