Use of clomipramine in the treatment of anxiety-related and obsessive-compulsive disorders in cats

Australian Veterinary Journal
K Seksel, M J Lindeman

Abstract

To evaluate the efficacy and tolerance of a treatment protocol for anxiety-related and obsessive-compulsive disorders in cats. A study was undertaken to assess the clinical response in cats diagnosed with anxiety-related or obsessive-compulsive disorders to a treatment regimen that included clomipramine and behaviour modification. The study group of 11 cats was acquired through referral. A detailed behavioural and clinical history was obtained. Presenting signs were urine spraying in seven cases, overgrooming in three and excessive vocalisation in one. Clomipramine was administered orally once daily. The mean starting dose was 0.4 mg/kg. If necessary, the dose was adjusted according to the clinical response of each cat. A behaviour modification program was designed and the owner instructed on its implementation. Cats were to continue on medication for at least 1 month after clinical signs disappeared, then medication withdrawal was to be attempted by decreasing the clomipramine dose progressively at weekly intervals while the behaviour modification program continued. In all cases the presenting clinical sign was largely improved or disappeared. One cat was removed from the study by the owner. Four cats became lethargic at highe...Continue Reading

References

Mar 1, 1991·The Veterinary Clinics of North America. Small Animal Practice·U A LuescherJ Halip
Oct 1, 1985·Archives of General Psychiatry·M F FlamentM Linnoila
May 1, 1997·The Veterinary Clinics of North America. Small Animal Practice·L L Cooper
May 1, 1997·The Veterinary Clinics of North America. Small Animal Practice·K L Overall

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Citations

May 5, 2004·Journal of Feline Medicine and Surgery·Karen L Overall
Apr 29, 2011·PloS One·Daniel S MillsGary M Landsberg
Dec 3, 2002·Journal of the American Veterinary Medical Association·Karen L Overall, Arthur E Dunham
Jan 7, 2005·Journal of the American Animal Hospital Association·Gary M Landsberg, Andrea L Wilson
Sep 9, 2006·Journal of the American Animal Hospital Association·Petra A MertensCarl Jessen
Jul 9, 2004·Journal of the American Animal Hospital Association·Lynne M SeibertBranson W Ritchie
Apr 29, 2014·The Veterinary Clinics of North America. Small Animal Practice·Valarie V Tynes, Leslie Sinn
Mar 31, 2004·The Journal of Small Animal Practice·M E CameronD A Gunn-Moore
Apr 15, 2004·Australian Veterinary Journal·M Low
Jul 19, 2006·Journal of Veterinary Pharmacology and Therapeutics·C LainesseM Doucet
Sep 7, 2007·Journal of Veterinary Pharmacology and Therapeutics·C LainesseM Doucet
May 20, 2015·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Dónal J O'Leary
Oct 17, 2018·Journal of Applied Animal Welfare Science : JAAWS·Temple Grandin
Jun 3, 2006·Journal of the American Veterinary Medical Association·Stephen E WaisglassJan A Hall
Oct 16, 2004·Journal of the American Veterinary Medical Association·Jonathan N KingUNKNOWN CLOFUS Study Group
Mar 7, 2003·Journal of the American Veterinary Medical Association·Bonnie G Campbell
Apr 22, 2010·The Journal of Family Planning and Reproductive Health Care·Julia Wilkens, Hilary Critchley
Oct 31, 2020·Journal of Medicinal Chemistry·Kevin A ScottJon T Njardarson

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