Abstract
Levodopa-induced psychosis can complicate the treatment of Parkinson's disease (PD). In this retrospective, uncontrolled report, we describe our experience treating PD-related psychosis with clozapine, emphasizing those patients treated for longer than 1 year. Twenty-seven patients were treated, 14 for longer than 1 year. Most patients showed a rapid improvement from baseline within 1 month using the Clinical Global Impression and Global Psychosis Rating Scores. Five patients discontinued the drug due to side effects, but only two patients reported side effects after 6 months of treatment. Clozapine appears to be effective in treating PD related psychotic symptoms while not interfering with motor function.
References
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jul 1, 1992·General Hospital Psychiatry·S H RosenthalD S Harnett
Jan 1, 1991·Schizophrenia Bulletin·J Gerlach
Oct 1, 1991·Neurology·N KahnR L Watts
May 1, 1990·Neurology·E C WoltersD B Calne
Jan 1, 1990·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·P A FischerR Hefner
Jan 1, 1990·Movement Disorders : Official Journal of the Movement Disorder Society·J H Friedman, M C Lannon
Jan 1, 1990·Movement Disorders : Official Journal of the Movement Disorder Society·R F PfeifferJ Wilson
Jul 1, 1990·Neurology·F Bernardi, M Del Zompo
Jan 1, 1989·The Journal of Neuropsychiatry and Clinical Neurosciences·H E RobertsA Stoudemire
Sep 1, 1989·Neurology·J H Friedman, M C Lannon
Mar 1, 1986·Acta Neurologica Scandinavica·H Pakkenberg, B Pakkenberg
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Mar 1, 1994·Neurology·S A FactorG D Podskalny
Jun 1, 1993·Journal of the American Geriatrics Society·M F Lew, C H Waters
Jan 1, 1996·The Journal of Neuropsychiatry and Clinical Neurosciences·W S Musser, M Akil
Citations
Jun 1, 2006·CNS Drugs·Caroline H Williams-GrayRoger A Barker
Jun 13, 2003·The Journal of Head Trauma Rehabilitation·Elie Paul ElovicJoseph H Ricker
Mar 20, 2013·Journal of Psychiatric Practice·Rosa Quelhas
Dec 18, 2019·Psychiatry and Clinical Neurosciences·Natalie SeilerBrian O'Donoghue
May 15, 2015·Clinical Neuropharmacology·Unax LertxundiJuan Carlos García-Moncó