PMID: 9188021Apr 1, 1997Paper

Use of clozapine to treat levodopa-induced psychosis in Parkinson's disease: retrospective review

Journal of Geriatric Psychiatry and Neurology
L P WidmanD McArthur-Campbell

Abstract

Levodopa-induced psychosis can complicate the treatment of Parkinson's disease (PD). In this retrospective, uncontrolled report, we describe our experience treating PD-related psychosis with clozapine, emphasizing those patients treated for longer than 1 year. Twenty-seven patients were treated, 14 for longer than 1 year. Most patients showed a rapid improvement from baseline within 1 month using the Clinical Global Impression and Global Psychosis Rating Scores. Five patients discontinued the drug due to side effects, but only two patients reported side effects after 6 months of treatment. Clozapine appears to be effective in treating PD related psychotic symptoms while not interfering with motor function.

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Citations

Jun 13, 2003·The Journal of Head Trauma Rehabilitation·Elie Paul ElovicJoseph H Ricker
Mar 20, 2013·Journal of Psychiatric Practice·Rosa Quelhas
Dec 18, 2019·Psychiatry and Clinical Neurosciences·Natalie SeilerBrian O'Donoghue
May 15, 2015·Clinical Neuropharmacology·Unax LertxundiJuan Carlos García-Moncó

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