Use of complementary and alternative medicines is associated with delay to initiation of disease-modifying anti-rheumatic drug therapy in early inflammatory arthritis

International Journal of Rheumatic Diseases
Manjari LahiriPeter P M Cheung

Abstract

To study the predictors of complementary and alternative medicine (CAM) use in patients with early inflammatory arthritis (EIA), and its impact on delay to initiation of disease-modifying anti-rheumatic drugs (DMARD). Data were collected prospectively from EIA patients aged ≥ 21 years. Current or prior CAM use was ascertained by face-to-face interview. Predictors of CAM use and its effect on time to DMARD initiation were determined by multivariate logistic regression and Cox proportional hazards, respectively. One hundred and eighty patients (70.6% female, 58.3% Chinese), of median (interquartile range [IQR]) age 51.1 (40.9-59.8) years and symptom duration 16.6 (9.2-26.6) weeks were included: 83.9% had rheumatoid arthritis, 57% were seropositive. Median (IQR) Disease Activity Score in 28-joints (DAS28) was 4.3 (2.8-5.7), modified Health Assessment Questionnaire (mHAQ) was 0.38 (0.0-0.88) and 41.3% were CAM users. Chinese race (odds ratio [OR] 5.76 [95%CI 2.53-13.1]), being non-English speaking (OR 2.68 [95% CI 1.18-6.09]), smoking (OR 3.35 [95% CI 1.23-9.15] and high DAS28 (OR 2.73 [95% CI 1.05-7.09] were independent predictors of CAM use. CAM users initiated DMARD later (median [IQR] 21.5 [13.1-30.4] vs. 15.6 [9.4-22.7] weeks ...Continue Reading

References

Jun 9, 1998·Journal of Epidemiology and Community Health·G Davey SmithV Hawthorne
Jan 13, 2010·Rheumatology International·Elaudi Rodríguez-PolancoMartín A Rodríguez
Aug 20, 2010·Arthritis and Rheumatism·Michael P M van der LindenAnnette H M van der Helm-van Mil
May 17, 2011·The Journal of Rheumatology·Shahin JamalClaire Bombardier
Jun 10, 2011·Rheumatology·Gary J MacfarlaneUNKNOWN Arthritis Research UK Working Group on Complementary and Alternative Medicines
Nov 29, 2011·Rheumatology·Manjari LahiriIan N Bruce
Jun 5, 2012·Rheumatology·Gary J MacfarlaneUNKNOWN Arthritis Research UK Working Group on Complementary and Alternative Therapies for the Management of the Rheumatic Diseases
Aug 29, 2013·Arthritis Care & Research·Ashutosh TamhaneLeigh F Callahan
Sep 21, 2013·Scandinavian Journal of Rheumatology·D De CockUNKNOWN CareRA study group*
Jan 7, 2014·Annals of the Rheumatic Diseases·D P C de RooyA H M van der Helm-van Mil
Feb 19, 2014·Annals of the Rheumatic Diseases·Jan SørensenUNKNOWN all departments of rheumatology in Denmark
Jun 30, 2015·The International Journal of Health Planning and Management·Nakul SaxenaPhilip Choo
Jun 10, 2016·British Journal of Nursing : BJN·J FirthUNKNOWN BSR National Audit Project Working Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.