PMID: 6229993Jan 15, 1984Paper

Use of computerized tomography to assess myocardial infarct size and ventricular function in dogs during acute coronary occlusion and reperfusion

The American Journal of Cardiology
G B ManciniC B Higgins

Abstract

Prospectively ECG-gated and nongated computed tomography (CT) can be used to assess global and regional left ventricular (LV) function and to measure myocardial infarct (MI) size. In the current study, CT was used to assess the effects of coronary occlusion and reperfusion in 16 dogs. Ten dogs were subjected to permanent occlusion of the proximal left anterior descending coronary artery and 6 dogs were reperfused after a 2-hour period of total coronary occlusion. Gated scans were used to quantitate the extent of wall thickening in the ischemic zone and to assess changes in mid-LV cross-sectional chamber area at end-diastole and end-systole. Nongated scans were used to estimate the size of the initial perfusion defect during contrast injection shortly after coronary occlusion and the size of the MI as indicated by delayed enhancement of the infarct 10 to 30 minutes after cessation of contrast administration. Neither group showed significant changes in end-diastolic chamber area during acute occlusion or 3 days later. Both groups showed a significant deterioration in percent change in chamber area both early after coronary occlusion and 3 days later; however, in the permanent occlusion group, percent wall thickening in the ischem...Continue Reading

References

May 1, 1978·Radiology·S J HesselH L Abrams
Jun 1, 1978·Chest·M C FishbeinP R Maroko
Jan 1, 1979·The American Journal of Cardiology·C B HigginsP T Siemers
Aug 1, 1974·Circulation·E Braunwald, P R Maroko
Sep 5, 1974·The New England Journal of Medicine·W E Shell, B E Sobel
Oct 1, 1972·Circulation·B E SobelR D Yoder
Mar 1, 1981·AJR. American Journal of Roentgenology·D J HuberS J Hessel
Apr 1, 1983·Journal of the American College of Cardiology·S G EllisR A Kloner
Jan 1, 1982·Investigative Radiology·J D NewellJ L Abraham
May 1, 1980·Investigative Radiology·J D NewellF Haigler

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