Use of contraception by women treated with leflunomide due to rheumatic arthritis

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
T BanasB Batko

Abstract

A total of 46 premenopausal patients treated with leflunomide (LMF) for rheumatic arthritis (RA) and 107 women of reproductive age free from chronic diseases were investigated to evaluate methods of contraception. Among 31 LMF-treated women using contraception, 48.4% chose oestrogen-progesterone hormonal contraception (E-PHC); 16.1% condoms; 3.2% had an intrauterine device and 32.0% preferred natural methods. These methods differed significantly from women in the control group, who mostly used condoms (56.8%) and E-PHC (35.3%) and rarely, natural methods (3.95%) or progesterone injections (3.95%). As many as 32.6% LMF-treated patients did not use any method of birth control. The choice of contraception among RA patients with LFM therapy was significantly dependent on the experience with methods used prior to the LFM therapy introduction (p < 0.001). Compared with women free from chronic diseases, LMF-treated patients use E-PHC significantly more often but still as many as 33% do not use any contraceptive method, despite strong recommendations.

References

Apr 23, 2002·Teratology·Kenneth Lyons JonesChristina D Chambers
Aug 3, 2004·Annals of the Rheumatic Diseases·T Uhlig, T K Kvien
Apr 13, 2005·Autoimmunity Reviews·Yannis Alamanos, Alexandros A Drosos
Oct 1, 2005·Seminars in Arthritis and Rheumatism·Katherine K TempranoTerry L Moore
Aug 31, 2006·Clinical Rheumatology·Ahmet IsikOsman Mermi
Nov 25, 2006·Clinical Rheumatology·Janine G Walker, Geoffrey O Littlejohn
Mar 3, 2007·Clinical Rheumatology·Eva PalkonyaiEszter Meszaros
Jul 25, 2007·Clinical Rheumatology·Cesar Ramos-RemusGregorio Navarro-Cano
Dec 23, 2009·The Journal of Obstetrics and Gynaecology Research·Sergio BigolinAnna Luiza Negrini Fagundes
Feb 5, 2010·Arthritis and Rheumatism·Christina D ChambersUNKNOWN Organization of Teratology Information Specialists Collaborative Research Group
Dec 2, 2010·Rheumatology International·Rosamund Partlett, Euthalia Roussou

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Citations

Mar 20, 2018·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Milena Bastos BritoMittermayer Santiago
Sep 21, 2016·Menopause : the Journal of the North American Menopause Society·Tomasz BanasInga Ludwin
Sep 13, 2020·Birth Defects Research·Wejdan A ShroukhSarah C Willis
Sep 16, 2017·Experimental and Therapeutic Medicine·Danyan BiHuayou Luo

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