PMID: 6411430Jun 1, 1983Paper

Use of cost-effectiveness analysis in planning cancer chemoprophylaxis trials

Controlled Clinical Trials
H A Guess, S A Rudnick

Abstract

We present a conceptual framework for the use of cost-effectiveness analysis in planning cancer chemoprophylaxis trials and evaluating such choices as sample size, study design, diagnostic evaluation, and duration of follow-up. The approach is illustrated by cost-effectiveness calculations for a trial of synthetic retinoids as cancer prophylaxis agents. Our work emphasizes the need for studies large enough to have a reasonable power of detecting 10%-20% reductions in mortality. Conversely, we note that rare but serious idiosyncratic side effects such as those seen the the "swine-flu" vaccination program are likely to escape detection even in trials involving tens of thousands of subjects.

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Citations

Sep 1, 1987·Controlled Clinical Trials·S Piantadosi, B Patterson
Apr 1, 1990·Controlled Clinical Trials·N UrbanS L Gorbach
Aug 31, 2010·Medicina clínica·Carlos SalinasAlberto Capelastegui
Jul 2, 2002·Lancet·Elizabeth L CorbettRichard J Hayes
Feb 14, 2006·American Journal of Respiratory and Critical Care Medicine·Mauro SchechterRichard E Chaisson
Jun 1, 1997·Journal of Travel Medicine·S Houston
Aug 1, 1987·Cancer·R P Gibbons
Jul 2, 2014·Clinical Trials : Journal of the Society for Clinical Trials·Lynn HuynhMilo A Puhan

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