Use of cyclosporine 0.05% ophthalmic emulsion for contact lens-intolerant patients

Eye & Contact Lens
Milton M Hom

Abstract

To evaluate the effect of cyclosporine 0.05% ophthalmic emulsion (Restasis, Allergan, Inc., Irvine, CA) on contact lens comfort and reducing dry eye symptoms in patients with contact lens intolerance. A 5-week, randomized, investigator-masked study of 17 patients with self-reported contact lens-related dryness. Patients were randomized to cyclosporine twice per day or rewetting drops (carboxymethylcellulose 0.5%, Refresh Contacts) twice per day, to be used before and after lens wear. Changes from baseline in fluorescein staining of the cornea and conjunctiva and in tear breakup time were used to determine improvement of dry eye signs. Symptoms were assessed by lens wear time, use of rewetting drops during lens wear, subjective evaluation of dryness, and the completion of the Ocular Surface Disease Index questionnaire. Five weeks of cyclosporine treatment significantly improved dry eye symptoms (mean improvement of 0.88 +/- 0.64 with cyclosporine; no change of 0 +/- 0.58 [P = 0.01] with rewetting drops). Patients using cyclosporine decreased the use of rewetting drops by a mean 1.0 +/- 1.1 drops per day, and patients using rewetting drops increased their use (mean increase of 0.86 +/- 1.1 drops per day [P = 0.032]). Wearing time...Continue Reading

References

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Citations

Oct 25, 2006·International Ophthalmology Clinics·Gary N Foulks
Sep 17, 2013·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Robin Chalmers
Jan 9, 2008·Eye & Contact Lens·Christi M WillenCarol Rosenstiel
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Dec 2, 2020·Journal of Cataract and Refractive Surgery·Rohit Shetty, Pooja Khamar

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