PMID: 3880820Jan 1, 1985Paper

Use of cyclosporine in pediatric renal transplant recipients

The Journal of Pediatrics
S ConleyB D Kahan

Abstract

Cyclosporine and prednisone were used in combination to produce immunosuppression in 18 pediatric recipients of renal allografts. Ten children received cadaveric kidneys and eight received kidneys from living related donors. With a mean follow-up of 16.5 months (range 7 to 33 months), the patient survival rate is 100% (18 of 18) and the graft survival rate is 83% (15 of 18). Two grafts were lost for nonimmunologic reasons. Currently the group mean (+/- SE) serum creatinine concentration is 1.22 +/- 0.11 mg/dl and creatinine clearance is 69.3 +/- 4.79 ml/min/1.73 m2. Cyclosporine nephrotoxicity has not caused irreversible allograft injury nor led to graft loss in this population. The incidence of treated rejection episodes has been 39% (seven of 18). Only 39% (seven of 18) of children have required hospital readmissions since the initial transplant discharge. There have been no opportunistic infections. In the 15 children with functioning grafts, some linear growth has occurred in 10 of 11 prepubertal and two of four postpubertal patients. Cyclosporine and prednisone have constituted a safe, efficacious immunosuppressive regimen for pediatric renal allograft recipients. Longer follow-up will be necessary to confirm whether these...Continue Reading

References

May 1, 1982·The Journal of Pediatrics·T E StarzlB W Shaw
Jan 1, 1981·The Journal of Pediatrics·C M FeldhoffS M Mauer
May 1, 1982·The Journal of Pediatrics·L C MillerS M Mauer

❮ Previous
Next ❯

Citations

May 1, 1987·American Journal of Diseases of Children·A H UrbachT E Starzl
Nov 1, 1988·European Journal of Pediatrics·F KrullJ Brodehl
Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·P F HoyerJ Brodehl
Apr 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G OffnerR Pichlmayr
Apr 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·D F GearyG Arbus
Jul 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·V M ReznikS A Mendoza
Jul 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·U B Berg, A B Bohlin
Jan 1, 1988·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·P F HoyerJ Brodehl
Sep 1, 1987·The Japanese Journal of Surgery·T YasumuraT Hamajima
Jul 1, 1988·Indian Journal of Pediatrics·D B Gradus, R N Fine
Nov 4, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tania ClaeysRita Van Damme-Lombaerts
Mar 26, 2004·Transplantation Proceedings·L PapeG Offner
Dec 1, 1987·The Journal of Pediatrics·B D KahanC Van Buren
Jun 20, 1987·Lancet·V M ReznikS A Mendoza
Jun 1, 1990·Acta paediatrica Scandinavica·P F HoyerR Pichlmayr
Feb 1, 1988·Archives of Disease in Childhood·G OffnerJ Brodehl
Apr 1, 1986·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P T McEneryA Tejani
Apr 29, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·John C MageeEric N Mendeloff
Nov 14, 2006·Pediatric Transplantation·Raman Venkataramanan, Rakesh Sindhi
Nov 14, 2006·Pediatric Transplantation·Asher D SchachterWilliam E Harmon
Oct 1, 2002·Paediatrics & Child Health·Guido Filler, Janusz Feber
Oct 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R G WalkerP Kincaid-Smith
Jul 4, 1988·The Medical Journal of Australia·R G WalkerP Kincaid-Smith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
G OffnerR Pichlmayr
Archives of Disease in Childhood
M H Winterborn
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
P F HoyerJ Brodehl
© 2021 Meta ULC. All rights reserved