Use of del Nido cardioplegia in acute aortic dissection surgery.

Perfusion
HongWei ChenXin Chen

Abstract

Del Nido cardioplegia solution provides a depolarized hyperkalemic arrest lasting up to 60 minutes. Single-dose del Nido cardioplegia solution may offer an alternative myocardial protection strategy to conventional whole blood cardioplegia following acute aortic dissection surgery. We retrospectively reviewed 122 consecutive patients with acute aortic dissection undergoing arch reconstruction surgery procedure with cardioplegia arrest from January 2017 to December 2019. Patients exclusively received with whole blood cardioplegia (n = 60, January 2017-December 2018) or del Nido cardioplegia (n = 62, January 2018-December 2019). Preoperative and postoperative data were retrospectively reviewed. No significant difference between two groups in mortality (4/60 vs 3/62, p = 0.964), cardiopulmonary bypass time (168.0 ± 10.5 minute vs 165.0 ± 12.5 minute, p = 0.154), aortic cross-clamp time (91.8 ± 9.0 minute vs 93.2 ± 9.5 minute, p = 0.405), selective antegrade cerebral perfusion time (21.8 ± 5.0 minute vs 22.4 ± 4.7 minute, p = 0.496) and postoperative vasoactive inotropic score (34.8 ± 1.9 vs 35.2 ± 2.1, p = 0.272), neurological complications rate (8/60 vs 12/62, p = 0.523), renal insufficiency rate (5/60 vs 7/62, p = 0.807) and the...Continue Reading

References

Oct 2, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Michael G GaiesJennifer C Hirsch
Aug 21, 2013·The Journal of Thoracic and Cardiovascular Surgery·Arun GovindapillaiStacy B O'Blenes
May 28, 2014·Journal of Cardiac Surgery·Robert A SorabellaIsaac George
Dec 9, 2014·The Journal of Thoracic and Cardiovascular Surgery·Stephanie L MickJoseph F Sabik
Oct 9, 2015·Perfusion·George Jose ValooranCyril Dominic
Jul 19, 2018·General Thoracic and Cardiovascular Surgery·Kazumasa Orihashi
Aug 10, 2018·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Haci Ali Ucak, Hasan Uncu

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