Use of dense granule antigen GRA6 in an immunoglobulin G avidity test to exclude acute Toxoplasma gondii infection during pregnancy.

Clinical and Vaccine Immunology : CVI
Hossein ElyasiMajid Golkar

Abstract

The usefulness of a specific immunoglobulin G (IgG) avidity enzyme-linked immunosorbent assay (ELISA) based on recombinant GRA6 antigen for distinguishing between acute and chronic Toxoplasma infection was investigated. Two sets of serum samples obtained from pregnant women with acute, chronic, or no Toxoplasma infection collected in France and Iran were used. Among the French subjects, 19 of 20 (95%) women who experienced seroconversion during the past 4 months before sampling displayed low-avidity IgG antibodies against GRA6, while all 17 (100%) women with chronic infection had high-avidity antibodies. When the Euroimmun IgG avidity ELISA was used, 15 of 19 (78.9%) recently infected women had low-avidity antibodies, and 20 of 22 (90.9%) women with chronic infection displayed high-avidity antibodies. The results suggested better performance of the GRA6 avidity ELISA than the Euroimmun avidity ELISA for exclusion of a recent infection occurring less than 4 months previously. Similarly, all 35 Iranian women with acute Toxoplasma infection had low-avidity antibodies against GRA6, whereas all 34 women with chronic infection displayed IgG antibodies of high avidity, indicating the value of GRA6 avidity testing for ruling out a rece...Continue Reading

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Citations

Jul 27, 2012·Scandinavian Journal of Infectious Diseases·Geita Saadatnia, Majid Golkar
Feb 24, 2015·Diagnostic Microbiology and Infectious Disease·Dorota DrapałaJózef Kur
Sep 24, 2016·The Korean Journal of Parasitology·Yanhua WangJian Ping Cai
Apr 9, 2013·Revista Do Instituto De Medicina Tropical De São Paulo·Poonam S DeshpandeFatemeh Ghaffarifar
Apr 27, 2018·Biomarkers in Medicine·Juan Gabriel Costa, María Julia Vilariño
Oct 4, 2012·Journal of Leukocyte Biology·Florence PersatClaude Vincent
Sep 23, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Juan G CostaIván S Marcipar
May 28, 2020·Frontiers in Cellular and Infection Microbiology·Rochelle Haidee D YbañezYoshifumi Nishikawa
Apr 26, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C GarnaudUNKNOWN under the auspices of the ESGCP of ESCMID

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