Use of Dental Pulp Stem Cells/Collagen Sponge Biocomplex in the Treatment of Non-Contained Intrabony Defects: A Case Series

Clinical Advances in Periodontics
Mario AimettiFederica Romano

Abstract

Because of their accessibility and biologic features, dental pulp stem cells (DPSCs) hold great promise for regeneration in clinical applications. To the best of the authors' knowledge, no data are available concerning their regenerative potential in human periodontal intrabony defects. The present case series explores the clinical and radiographic effectiveness of autologous DPSCs/collagen sponge biocomplex in the treatment of non-contained intrabony defects in patients with chronic periodontitis. Four healthy patients displaying at least one prevalently 1- or 2-wall intrabony defect and one vital third molar requiring extraction were consecutively included in the study. Before surgery, patients were enrolled in a strict periodontal program including oral hygiene instructions and scaling and root planing. The third molar was extracted and used as the autologous DPSC source. The dental pulp was mechanically dissociated and filtered through 50-μm pores to obtain a cellular suspension enriched in stem cells. The selected intrabony defects, one per patient, were filled with the cellular suspension endorsed onto a collagen sponge. The mean probing depth decreased from 8.0 ± 0.8 mm at baseline to 3.3 ± 1.0 mm at the 12-month evaluat...Continue Reading

References

Feb 1, 1976·Journal of Clinical Periodontology·J Caton, H A Zander
Apr 1, 1993·Journal of Periodontology·P CortelliniM S Tonetti
Jun 23, 2000·Annals of Periodontology·G C Armitage
Mar 1, 2006·Biomaterials·Yoshinori SumitaMinoru Ueda
Mar 1, 2009·International Journal of Oral Science·Li PengXue-dong Zhou
Aug 24, 2013·The Journal of Oral Implantology·Afshin KhorsandShahrbanoo Jahangir

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Citations

Dec 22, 2019·Journal of Oral Biosciences·Deborah SybilSyed Akhtar Husain

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