PMID: 2104471Jan 1, 1990Paper

Use of derivative UV spectroscopy to monitor the percutaneous absorption of befunolol-HCL

Yao xue xue bao = Acta pharmaceutica Sinica
L Yang, J M Zheng

Abstract

Second-order derivative UV spectroscopy was used to measure the transfer of befunolol-HCl across full-thickness rabbit skin in vitro. The effect of penetration enhancers, azone-PG and PEG-400, on permeation course of befunolol-HCl was studied. A type of horizontal diffusion cell was employed. Permeability coefficients were measured in normal saline and in solutions containing the enhancing agents. The results indicated that befunolol-HCl may be an interesting candidate for transdermal administration and azone-PG highly and significantly increases the skin permeation of the drug in the solvent system tested.

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