Use of desmopressin and concomitant use of potentially interacting drugs in elderly patients in Sweden

European Journal of Clinical Pharmacology
Rickard Ljung

Abstract

The aims of this study were to analyze the prescription pattern of desmopressin before and after the new indication was approved for treatment of nocturia in the elderly in Sweden in 2002 and to analyze to what extent other drugs potentially inducing hyponatremia were prescribed in combination with desmopressin. We conducted epidemiological analyzes of the Swedish Prescribed Drug Register from 2000 to March 2007. All patients older than 60 years who were prescribed desmopressin in Sweden during the study period were included. A marked increase in filled prescriptions of desmopressin in elderly patients was noticed after the new approval in 2002. The therapeutic intensity peaked in 2005 and has thereafter markedly decreased. The magnitude of concurrent treatment with any of the following drugs was assessed: diuretics, tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRI), chlorpromazine, carbamazepine, loperamide, and nonsteroid anti-inflammatory drugs. More than half of the patients on desmopressin during July 2005 and March 2007 filled a prescription of any of the potentially harmful drugs within 30 days of a filled prescription of desmopressin. The use of desmopressin in the elderly after the new approval ...Continue Reading

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Citations

Feb 10, 2012·Analytical and Bioanalytical Chemistry·Simone EspositoPeter Van Eenoo
Mar 1, 2010·Tijdschrift voor gerontologie en geriatrie·T Ten DoesschateJ A H R Claassen
May 27, 2016·Journal of the American Geriatrics Society·Ahmet YalcinTeslime Atli

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