Use of Detomidine Oromucosal Gel for Alleviation of Acute Anxiety and Fear in Horses: A Pilot Study

Frontiers in Veterinary Science
Francesca DaiMichela Minero

Abstract

The aim of this randomized, double-blind, placebo-controlled, parallel group clinical field study was to evaluate the effect of detomidine oromucosal gel in alleviating anxiety and fear in horses. Sixteen horses with a history of acute anxiety and fear associated with firework-related noise entered the study. On New Year's Eve, eight horses were treated with 30 μg/kg detomidine gel and eight horses with placebo gel. When fireworks were present, 75% (6/8) of the detomidine-treated horses were scored by their owners as having a good or excellent treatment effect on anxiety and fear, while 50% (3/6) of horses receiving placebo were scored to have a good effect. Horses' behavior was video-recorded and assessed with a focal animal continuous method by a treatment-blind expert observer. Results showed that when fireworks were present, walking behavior decreased significantly (p < 0.05) after treatment with detomidine and that horses of the placebo group, overall, showed more restlessness, vocalization, and signs of colic (Wilcoxon matched-pairs test on the first PC, p = 0.007). This study indicates that detomidine oromucosal gel can be used to alleviate acute noise-related anxiety and fear in horses, but larger treatment groups are n...Continue Reading

References

Jan 31, 2002·Anesthesiology·UNKNOWN American Society of Anesthesiologists Task Force on Preanesthesia Evaluation
Nov 25, 2003·The Veterinary Record·D S MillsC Shorthouse
Nov 30, 2007·Physiology & Behavior·B ForkmanR B Jones
Dec 18, 2007·Equine Veterinary Journal·J W ChristensenL J Keeling
Feb 26, 2010·Veterinary Research Communications·Birgit FlaugerErich Möstl
Jan 12, 2011·Journal of Veterinary Pharmacology and Therapeutics·H KaukinenJ S Salonen
Mar 24, 2016·Animals : an Open Access Journal From MDPI·Gabriella GronqvistErica Gee
Oct 1, 2019·Journal of Veterinary Internal Medicine·Odilo EngelDaniel Simon Mills

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