Use of dexmedetomidine and opioids as the primary anesthetic in infants and young children: A retrospective cohort study.

Paediatric Anaesthesia
Proshad N EfunePeter Szmuk

Abstract

Anesthetic regimens using dexmedetomidine and short-acting opioids have been suggested as potential alternatives to sevoflurane-based anesthesia in children. The primary aim of this study is to compare demographics, intraoperative characteristics, and complications of general anesthetics in which dexmedetomidine and opioids were used without sevoflurane, or in combination with a low sevoflurane concentration, in children 36 months old and younger. The secondary aim is to evaluate intraoperative bispectral index (BIS) values when available in these patients. General anesthetics performed between January 1, 2017, and May 1, 2018, in children 2 years and younger who received dexmedetomidine and remifentanil, with or without sevoflurane, were identified. Additional anesthetics performed during this time in children 36 months and younger who received dexmedetomidine and opioids and had BIS monitoring were also identified. Charts were reviewed for demographic and intraoperative variables, including drug administration and hemodynamic data. A total of 244 patients were identified. All but 22 patients received remifentanil. Ninety-two patients received sevoflurane with a mean end-tidal concentration of 0.84% (SD 0.43). Compared to the ...Continue Reading

References

Jan 24, 2006·Anesthesia and Analgesia·Senthilkumar SadhasivamMehernoor F Watcha
Apr 19, 2006·Paediatric Anaesthesia·Andrew J Davidson
Sep 29, 2007·Best Practice & Research. Clinical Anaesthesiology·Andrew J Davidson
Apr 20, 2011·Anaesthesia·A J DavidsonF Weber
Jan 4, 2013·British Journal of Anaesthesia·M E McCann, S G Soriano
Dec 26, 2015·Anesthesiology and Pain Medicine·M-Irfan SulemanM-Saif Siddiqu
Jun 9, 2016·JAMA : the Journal of the American Medical Association·Lena S SunFrancis X McGowan
Feb 9, 2017·The New England Journal of Medicine·Dean B Andropoulos, Michael F Greene
Jul 5, 2018·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Ellise CappuccioJoseph D Tobias
Aug 22, 2018·Journal of Anesthesia·Li-Jun BoZhen-Ming Dong
Oct 8, 2019·JAMA Pediatrics·Ethan L SanfordPeter Szmuk

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Citations

Feb 5, 2021·Paediatric Anaesthesia·Patrick StaffordBishr Haydar

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