Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Matthew A SpinelliMonica Gandhi

Abstract

Cases of seroconversion on pre-exposure prophylaxis (PrEP) should be carefully investigated, given their public health implications and rarity. We report a case of transmitted drug resistance causing seroconversion on PrEP in spite of high adherence, confirmed with dried blood spot and segmental hair drug-level testing and single-genome sequencing.

References

Sep 14, 2012·Science Translational Medicine·Peter L AndersonUNKNOWN iPrEx Study Team
Apr 18, 2014·The Journal of Infectious Diseases·Teri LieglerUNKNOWN iPrEx Study Team
Nov 17, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Julia L MarcusJonathan E Volk
Feb 2, 2017·The New England Journal of Medicine·David C KnoxDarrell H S Tan
Sep 19, 2017·The Lancet. HIV·Elske HoornenborgUNKNOWN Amsterdam PrEP Project team in the HIV Transmission Elimination AMsterdam Consortium (H-TEAM)
Oct 28, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Martin MarkowitzHiroshi Mohri
Jul 3, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Donn J ColbyNittaya Phanuphak
Aug 1, 2019·Future Healthcare Journal·Mohan MishraUdbhatt Mishra

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