Use of Dual-Ligand Modification in Kupffer Cell-Targeted Liposomes To Examine the Contribution of Kupffer Cells to Accelerated Blood Clearance Phenomenon

Molecular Pharmaceutics
Chaoyang LaiYanzhi Song

Abstract

The "accelerated blood clearance (ABC) phenomenon" is known to be involved in the adaptive immune system. Regretfully, the relationship between the ABC phenomenon and innate immune system, especially with respect to Kupffer cells (KCs) has been largely unexplored. In this study, the contribution of KCs to ABC was examined using the 4-aminophenyl-α-d-mannopyranoside (APM) lipid derivative DSPE-PEG2000-APM (DPM) and the 4-aminophenyl-β-l-fucopyranoside (APF) lipid derivative DSPE-PEG2000-APF (DPF) as ligands for mannose/fucose receptors on KCs, which were synthesized and modified on the surface of liposomes. The results of cellular liposome uptake in vitro and biodistribution in vivo indicated that DPM and DPF comodified liposomes (MFPL5-5) present the strongest capability of KC-targeting among all preparations tested. In rats pretreated with MFPL5-5 instead of PEGylated liposomes (PL), the ABC phenomenon was significantly enhanced and the distribution of liposomes in the liver was increased. Cellular uptake of the second injection of PL in vivo demonstrated that KCs was responsible for the uptake. Furthermore, compared to pretreatment with PL, the uptake of second injection of PL was more enhanced when pretreated with MFPL5-5. T...Continue Reading

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D PapahadjopoulosC Redemann
Apr 1, 1984·Biochemical Society Transactions·F H RoerdinkG L Scherphof
Jan 1, 1995·Journal of Gastroenterology and Hepatology·H TsukamotoM Lin
Oct 26, 2002·The Journal of Biological Chemistry·Lucy EastClare M Isacke
Feb 15, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Apr 4, 2003·International Journal of Pharmaceutics·Tatsuhiro IshidaHiroshi Kiwada
Oct 29, 2003·Current Opinion in Chemical Biology·John V Frangioni
Feb 18, 2004·World Journal of Gastroenterology : WJG·Xin ZhangJia-Zhang Xu
Mar 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xin Yu WangHiroshi Kiwada
May 24, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Mar 7, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Oct 3, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Nov 16, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Manfred BilzerAlexander L Gerbes
Feb 28, 2009·International Immunology·Taro Kawai, Shizuo Akira
Jul 28, 2009·Pharmaceutical Research·Tsutomu IshiharaTohru Mizushima
Dec 14, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yanling MaYihui Deng
Mar 1, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Klaas PoelstraLeonie Beljaars
Sep 12, 2012·Journal of Leukocyte Biology·Luisa Martinez-Pomares
Dec 12, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kouichi ShiraishiMasayuki Yokoyama
Mar 22, 2013·International Journal of Nanomedicine·Qingqing ChenJiao Sun
Aug 24, 2013·PloS One·Wei-qun ZengZuo-jin Liu
Sep 21, 2013·Nature Immunology·Luke C DaviesPhilip R Taylor
Jan 1, 2010·Pharmaceutics·Masako IchiharaHiroshi Kiwada
Dec 18, 2013·Immunology Letters·Pei-zhi LiKun He
Jul 22, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jantana YahuafaiNaoto Oku
Sep 4, 2015·Journal of Visualized Experiments : JoVE·Maxime BourgognonKhuloud T Al-Jamal
Dec 8, 2015·Nano Today·Heather Herd GustafsonHamidreza Ghandehari
Mar 8, 2017·Journal of Hepatology·Frank Tacke
Mar 18, 2017·Molecular Immunology·Peizhi LiJianping Gong
Jul 19, 2017·Colloids and Surfaces. B, Biointerfaces·Emma SamuelssonJoy Wolfram
May 1, 2017·Asian Journal of Pharmaceutical Sciences·Lirong WangYihui Deng

❮ Previous
Next ❯

Citations

Sep 3, 2020·Cells·Maximiliano L CacicedoMatthias Bros
Jun 24, 2020·Advanced Drug Delivery Reviews·Roland BöttgerShyh-Dar Li
Apr 24, 2021·Chemistry and Physics of Lipids·Pedro Henrique Correia de LimaRenato Márcio Ribeiro-Viana
May 29, 2021·Frontiers in Chemistry·Dongyoon KimChristoph Rademacher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.