Use of ebselen as a neuroprotective agent in rat spinal cord subjected to traumatic injury

Neural Regeneration Research
Wojciech ŚlusarczykWiesław Marcol

Abstract

Spinal cord injury (SCI) causes disturbances of motor skills. Free radicals have been shown to be essential for the development of spinal cord trauma. Despite some progress, until now no effective pharmacological therapies against SCI have been verified. The purpose of our experiment was to investigate the neuroprotective effects of ebselen on experimental SCI. Twenty-two rats subjected to SCI were randomly subjected to SCI with no further treatment (n = 10) or intragastric administration of ebselen (10 mg/kg) immediately and 24 hours after SCI. Behavioral changes were assessed using the Basso, Beattie, and Bresnahan locomotor scale and footprint test during 12 weeks after SCI. Histopathological and immunohistochemical analyses of spinal cords and brains were performed at 12 weeks after SCI. Magnetic resonance imaging analysis of spinal cords was also performed at 12 weeks after SCI. Rats treated with ebselen presented only limited neurobehavioral progress as well as reduced spinal cord injuries compared with the control group, namely length of lesions (cysts/scars) visualized histopathologically in the spinal cord sections was less but cavity area was very similar. The same pattern was found in T2-weighted magnetic resonance i...Continue Reading

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Citations

Dec 13, 2019·Antioxidants & Redox Signaling·Mathieu Chocry, Ludovic Leloup
Nov 24, 2020·Future Medicinal Chemistry·Jun WangLili Zou
Apr 2, 2021·Archives of Toxicology·Cristina W NogueiraJoão B T Rocha
Oct 23, 2019·Journal of Medicinal Chemistry·Ana Carolina RuberteDaniel Plano

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