Abstract
Persistent thrombocytopenia after stem cell transplantation can lead to increased morbidity and mortality [1,2]. The underlying causes are often multifactorial in this patient population [3,4]. In autologous transplantation, thrombocytopenia is usually a result of poor engraftment or a sign of impending disease relapse. In allogeneic stem cell transplantation, the etiology is often more complex with engraftment deficits, medication effects, graft versus host disease (GVHD), and other immunologic processes potentially contributing. Eltrombopag is an orally available nonpeptide thrombopoietin (TPO) receptor agonist which interacts with the transmembrane domain of the receptor on bone marrow megakaryocytes and upstream progenitor/stem cells. It has been studied in patients with chronic idiopathic thrombocytopenic purpura [5] and in patients with thrombocytopenia secondary to hepatitis C infection [6]. Unlike the case with recombinant human TPO, its use has not been associated with anti-platelet antibody production [7]. We report two cases of post-transplantation thrombocytopenia, one allogeneic and one autologous, where eltrombopag was given to treat prolonged thrombocytopenia. The use of eltrombopag in these two cases was effecti...Continue Reading
Citations
May 21, 2013·Expert Opinion on Biological Therapy·Simon HallamAdrian C Newland
Jan 20, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Takashi TanakaTakahiro Fukuda
May 13, 2015·International Journal of Hematology·Akihito FujimiJunji Kato
Apr 6, 2016·Transfusion Medicine·J DybaD S Allan
Jul 5, 2015·Annals of Hematology·Xiao-Hui ZhangXiao-Jun Huang
Oct 15, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jane L LiesveldYuhchyau Chen
Apr 21, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Zhuoyan LiBipin N Savani
Jun 12, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yu AkahoshiYoshinobu Kanda
Nov 5, 2016·Bulletin du cancer·Jérôme CornillonJean-Hugues Dalle
Jun 28, 2017·Pediatric Transplantation·Salah AliTal Schechter
Oct 17, 2015·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Megan E HartranftVamsi Kota
Jun 30, 2018·European Journal of Haematology·Anna Bosch-VilasecaJorge Sierra
Dec 21, 2018·Platelets·Yu-Qian SunXiao-Jun Huang
Jan 22, 2019·Bone Marrow Transplantation·Haixia FuLanping Xu
Feb 4, 2014·Transplantation·Zhu XishanRen Jun
Aug 16, 2019·Current Oncology Reports·Thomas F MichniackiSung Won Choi
Mar 23, 2018·Cell Transplantation·Noa Sher, Racheli Ofir
Dec 6, 2019·Blood·Régis Peffault de LatourGérard Socié
May 20, 2020·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Ram Vasudevan Nampoothiri, Rajat Kumar
Oct 23, 2015·Journal of Pediatric Hematology/oncology·Rahul NaithaniRajiv Uttam
Dec 13, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Upendra MahatRabi Hanna
Feb 27, 2021·The Lancet. Haematology·Katharina BaurAndreas Holbro
Apr 21, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Fei-Fei TangXiao-Jun Huang
Apr 23, 2021·International Journal of Hematology·Sabrina GiammarcoAndrea Bacigalupo
May 10, 2021·Transplantation and Cellular Therapy·Sairah AhmedUday Popat
Jun 11, 2021·Bone Marrow Transplantation·Ram Vasudevan NampoothiriRajat Kumar