Use of Emergency Medication in Adult Patients with Epilepsy: A Multicentre Cohort Study from Germany.

CNS Drugs
Jeannette KadelAdam Strzelczyk

Abstract

Emergency treatment with benzodiazepines is indicated in prolonged seizures, seizure clusters and status epilepticus. The aim of this study was to evaluate the use of emergency medication in adult patients with epilepsy. All adult epilepsy patients attending the epilepsy outpatient clinics of the university hospitals in Frankfurt and Marburg in 2015 were asked to participate in this questionnaire-based, retrospective survey. A total of 481 patients with a mean age of 43.4 years (range 18-94 years, 54% female) participated in the study. Among them, 134 patients (27.9%) reported on the prescription of an emergency medication during the last year. Patients receiving emergency medication were younger and exhibited a lower age at epilepsy onset, a higher seizure frequency and a higher number of regularly taken antiepileptic drugs. The most frequently taken emergency drugs were oral lorazepam tablets (65.7%; n = 88 out of 134), followed by buccal midazolam (23.9%, n = 32) and rectal diazepam (17.9%, n = 24). The most common indications for administering the emergency medication were seizures continuing for several minutes (35.1%, n = 47), but almost the same number of patients (33.6%, n = 45) stated that the rescue medication was giv...Continue Reading

References

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Mar 25, 2015·Seizure : the Journal of the British Epilepsy Association·Anna H NodaAdam Strzelczyk
Apr 25, 2017·Epilepsy & Behavior : E&B·Rohit ShankarMatthew Walker
Mar 28, 2018·CNS Drugs·Isabelle BeuchatAndrea O Rossetti

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Citations

Nov 5, 2019·Annals of Clinical and Translational Neurology·Lara KayAdam Strzelczyk
Jan 24, 2021·Seizure : the Journal of the British Epilepsy Association·Soraya MaierJohannes Rösche
Jul 16, 2021·Seizure : the Journal of the British Epilepsy Association·Adam StrzelczykSusanne Schubert-Bast

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