Use of enteric-coated mycophenolate sodium in de novo renal transplant recipients with high incidence of delayed graft function

Transplantation Proceedings
Ruben SchiavelliE Piulats

Abstract

Patients with delayed graft function (DGF) are at risk of increased incidence for acute rejection episodes (ARE). Mycophenolate mofetil or induction therapy has produced a reduction in ARE incidence. An open, prospective, 3-month trial was performed in a group of Argentinian renal transplant recipients. We recruited 46 patients, 71.7% men, aged 41.7 +/- 13.8 years; including 36 (78.3%) recipients of cadaveric donors (CD) who were aged 43.4 +/- 15.5 years with a cold ischemia time of 19.4 hours +/- 5.4 minutes, and 10 (27.7%) recipients of living donors (LD) aged 37.8 +/- 12.9 years. HLA mismatches >or= 3 were observed in 58.4% of CD and in 7% of LD. All patients received two doses of basiliximab (20 mg each, days 0 and 4), cyclosporine microemulsion (CsA-ME) monitored by the second-hour concentrations (C2), enteric-coated mycophenolate sodium (EC-MPS; 720 mg twice a day, and steroids. A 58% incidence of DGF was observed. At the end of the third month the incidence of biopsy-proven ARE was 15%, with a median serum creatinine of was 1.54 +/- 0.42 mg/dL, including three grafts lost. Two patients died. No patient required EC-MPS dose discontinuation but 20% of patients required dose adjustments. The absence of discontinuations and ...Continue Reading

References

Jan 1, 1999·Clinical Pharmacology and Therapeutics·M D HaleG A Verpooten
Nov 30, 2000·Journal of the American Society of Nephrology : JASN·Herwig-Ulf Meier-KriescheBruce Kaplan
Jun 5, 2003·Clinical Transplantation·Ronald P PelletierRonald M Ferguson
Feb 21, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Maurizio SalvadoriUNKNOWN ERL B301 Study Groups
Nov 2, 2004·Transplant International : Official Journal of the European Society for Organ Transplantation·Karen L HardingerMark A Schnitzler
Aug 18, 2005·BJU International·Pádraig J A DalyR William G Watson
Mar 30, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K BuddeP Glander

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Citations

Jul 22, 2017·The Cochrane Database of Systematic Reviews·Krishna M KarpeGiles D Walters

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