Use of enzyme replacement therapy for Gaucher disease during pregnancy

American Journal of Obstetrics and Gynecology
D ElsteinA Zimran

Abstract

To date there has been little published experience with enzyme replacement therapy in pregnant women with symptomatic type I Gaucher disease. We describe six patients, including three with repeated early pregnancy loss, five of whom successfully carried pregnancies to term; the last pregnancy was terminated because of pulmonary hypertension. All pregnancies were uneventful and five resulted in healthy newborns. We concluded that in patients with Gaucher disease of childbearing age,for whom obstetric complications are an important symptom of the disease, pregnancy is not contraindicated (unless there is evidence or suspicion of pulmonary hypertension) and treatment should not be interrupted because the clinical improvement engendered by enzyme replacement therapy is conducive to fewer complications during pregnancy and delivery and post partum.

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Citations

Jul 16, 2005·Hematology·Ari ZimranDeborah Elstein
Sep 24, 2009·Biologics : Targets & Therapy·Deborah Elstein, Ari Zimran
Apr 30, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N SakarelouH Michelakakis
Apr 10, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A M MamopoulosA B Mehta
Jan 1, 2012·Expert Opinion on Medical Diagnostics·Elena V PavlovaTimothy M Cox
Apr 13, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·H BoufettalN Samouh
Mar 23, 2010·La Presse médicale·Nadia Belmatoug, Djazia Heraoui
Apr 8, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Vera MalinováJirí Zeman
Mar 18, 2006·Clinical Genetics·H J MankinG M Pastores
Jul 28, 2007·British Journal of Haematology·Ernest Beutler
Mar 13, 2014·The Journal of Obstetrics and Gynaecology Research·Deborah ElsteinAri Zimran
Oct 13, 2004·International Journal of Obstetric Anesthesia·A IoscovichD Elstein
Mar 7, 2006·Molecular Genetics and Metabolism·Ernest Beutler
Jul 17, 2008·Expert Opinion on Pharmacotherapy·Neal J Weinreb
Feb 26, 2004·American Journal of Obstetrics and Gynecology·Yonatan ElsteinDeborah Elstein
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Oct 24, 2000·Blood Cells, Molecules & Diseases·E Beutler
Dec 4, 2004·PLoS Medicine·Ernest Beutler
Aug 7, 2002·São Paulo Medical Journal = Revista Paulista De Medicina·Maria Regina TorloniNelson Sass
Nov 18, 2018·Expert Review of Clinical Pharmacology·Punita Gupta, Gregory Pastores
Sep 6, 2000·British Journal of Haematology·D ElsteinA Zimran

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