Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement

The European Respiratory Journal
Luis Puente-MaestuSusan Ward

Abstract

This document reviews 1) the measurement properties of commonly used exercise tests in patients with chronic respiratory diseases and 2) published studies on their utilty and/or evaluation obtained from MEDLINE and Cochrane Library searches between 1990 and March 2015.Exercise tests are reliable and consistently responsive to rehabilitative and pharmacological interventions. Thresholds for clinically important changes in performance are available for several tests. In pulmonary arterial hypertension, the 6-min walk test (6MWT), peak oxygen uptake and ventilation/carbon dioxide output indices appear to be the variables most responsive to vasodilators. While bronchodilators do not always show clinically relevant effects in chronic obstructive pulmonary disease, high-intensity constant work-rate (endurance) tests (CWRET) are considerably more responsive than incremental exercise tests and 6MWTs. High-intensity CWRETs need to be standardised to reduce interindividual variability. Additional physiological information and responsiveness can be obtained from isotime measurements, particularly of inspiratory capacity and dyspnoea. Less evidence is available for the endurance shuttle walk test. Although the incremental shuttle walk test...Continue Reading

References

Mar 8, 1986·British Medical Journal·D P LipkinP A Poole-Wilson
May 29, 1982·British Medical Journal·R J ButlandD M Geddes
Jan 1, 1982·Medicine and Science in Sports and Exercise·J A DavisK Wasserman
Jan 1, 1982·Medicine and Science in Sports and Exercise·G A Borg
Dec 1, 1994·American Journal of Respiratory and Critical Care Medicine·A O Harris-EzeD D Marciniuk
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·F MaltaisR Belleau
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·F MaltaisR Belleau
Mar 1, 1997·Thorax·A J MoorcroftA K Webb
May 1, 1997·American Journal of Respiratory and Critical Care Medicine·R CasaburiC B Cooper
May 5, 1998·Medicine and Science in Sports and Exercise·M J FrancoD A Mahler
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·D E O'DonnellK A Webb
Oct 14, 1998·American Journal of Respiratory and Critical Care Medicine·T HajiroT Izumi
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·D E O'DonnellK A Webb
Apr 14, 2000·Journal of Cardiopulmonary Rehabilitation·W J RejeskiM J Berry
May 8, 2000·Journal of Applied Physiology·P PalangeS Carlone
Jun 15, 2000·British Journal of Sports Medicine·F S RamP N Black
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·J A NederB J Whipp

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Citations

Apr 27, 2016·Expert Review of Respiratory Medicine·Denis E O'DonnellJ Alberto Neder
Nov 8, 2016·Archivos de bronconeumología·Bruno-Pierre DubéPierantonio Laveneziana
Dec 20, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ling Ling Y TsaiZoe J McKeough
Jun 23, 2016·American Journal of Respiratory and Critical Care Medicine·Bartolome CelliUNKNOWN COPD Biomarker Qualification Consortium
Mar 1, 2017·Annals of the American Thoracic Society·Kim-Ly BuiDidier Saey
Jun 22, 2017·Respiration; International Review of Thoracic Diseases·Wouter H van GeffenDirk-Jan Slebos
Jul 19, 2017·Chronic Respiratory Disease·S L KarlssonNina Skavlan Godtfredsen
Apr 5, 2017·Annals of the American Thoracic Society·Jason WeatheraldPierantonio Laveneziana
Jun 8, 2017·Annals of the American Thoracic Society·Susan A WardDenny Z H Levett
Apr 12, 2017·Annals of the American Thoracic Society·Denis E O'DonnellUNKNOWN Canadian Respiratory Research Network
Dec 1, 2017·Medicine and Science in Sports and Exercise·Thomas W DecatoMatthew J Hegewald
Mar 6, 2018·Psychology, Health & Medicine·Guillaume ChevanceJulie Boiché
Nov 16, 2018·Chronic Respiratory Disease·Eléonore F van Dam van IsseltWilco P Achterberg
Sep 15, 2018·Congenital Heart Disease·Adikan BhasipolTarinee Tangcharoen
Aug 11, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Michele R SchaefferJordan A Guenette
Dec 20, 2017·ERJ Open Research·Alvar Agustí, Bartolomé Celli
Nov 24, 2017·The European Respiratory Journal·Gabor KovacsHorst Olschewski
Jan 4, 2017·The European Respiratory Journal·Marc HumbertNeil J Bullen
Jun 1, 2018·The European Respiratory Journal·Magnus EkströmPer Wollmer
Jun 1, 2018·The European Respiratory Journal·Marc BeaumontFrancis Couturaud
Feb 23, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Matteo Bonini, Giuseppe Fiorenzano
Mar 4, 2017·The European Respiratory Journal·Matthew MaddocksWilliam D-C Man
Sep 2, 2016·European Respiratory Review : an Official Journal of the European Respiratory Society·Pierantonio Laveneziana, Piergiuseppe Agostoni
Sep 2, 2016·European Respiratory Review : an Official Journal of the European Respiratory Society·Denis E O'DonnellDonald A Mahler
May 27, 2017·The European Respiratory Journal·Michele R SchaefferJordan A Guenette
Apr 21, 2017·The European Respiratory Journal·Denis E O'DonnellFrançois Maltais
Mar 10, 2017·The European Respiratory Journal·J Alberto NederDenis E O'Donnell
Feb 14, 2018·The European Respiratory Journal·Jason WeatheraldPierantonio Laveneziana
Jul 4, 2019·Current Opinion in Supportive and Palliative Care·Hayley LewthwaiteDennis Jensen
Jul 22, 2019·Journal of Clinical Medicine·Mara PaneroniMichele Vitacca
Nov 28, 2019·The European Respiratory Journal·Athénaïs BouclyPierantonio Laveneziana
May 6, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shinichi ArizonoYasuhiro Kondoh

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