Use of FDG PET/CT for investigation of febrile neutropenia: evaluation in high-risk cancer patients.

European Journal of Nuclear Medicine and Molecular Imaging
Stephen D GuyMonica A Slavin

Abstract

Febrile neutropenia (FNP) is a frequent complication of cancer care and evaluation often fails to identify a cause. [(18) F]FDG PET/CT has the potential to identify inflammatory and infectious foci, but its potential role as an investigation for persistent FNP has not previously been explored. The aim of this study was to prospectively evaluate the clinical utility of FDG PET/CT in patients with cancer and severe neutropenia and five or more days of persistent fever despite antibiotic therapy. Adult patients with a diagnosis of an underlying malignancy and persistent FNP (temperature ≥38°C and neutrophil count <500 cells/μl for 5 days) underwent FDG PET/CT as an adjunct to conventional evaluation and management. The study group comprised 20 patients with FNP who fulfilled the eligibility criteria and underwent FDG PET/CT in addition to conventional evaluation. The median neutrophil count on the day of the FDG PET/CT scan was 30 cells/μl (range 0-730 cells/μl). Conventional evaluation identified 14 distinct sites of infection, 13 (93 %) of which were also identified by FDG PET/CT, including all deep tissue infections. FDG PET/CT identified 9 additional likely infection sites, 8 of which were subsequently confirmed as "true posit...Continue Reading

References

May 6, 1993·The New England Journal of Medicine·P A Pizzo
Jun 3, 1998·British Journal of Haematology·A Y HoG J Mufti
Feb 19, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Walter T HughesLowell S Young
May 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marisa MiceliElias Anaissie
Oct 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T MahfouzE Anaissie
Dec 14, 2005·The Journal of Antimicrobial Chemotherapy·Mical PaulLeonard Leibovici
Nov 6, 2007·British Journal of Haematology·Penelope D Barnes, Kieren A Marr
Apr 24, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H Einsele, J Loeffler
Jul 20, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A HotO Lortholary
Jun 18, 2011·The Oncologist·Chantal P Bleeker-RoversWim J G Oyen
Sep 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M RuhnkeUNKNOWN Infectious Diseases Working Party in Haematology and Oncology of the German Society for Haematology and Oncology

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Citations

May 9, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Raghava KashyapMichael S Hofman
Jun 9, 2015·PET Clinics·Søren HessPoul Flemming Høilund-Carlsen
May 30, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Gijsbert J BlokhuisLioe-Fee de Geus-Oei
Jan 21, 2014·Academic Radiology·Søren HessAbass Alavi
Aug 3, 2013·Seminars in Nuclear Medicine·Fidel J VosWim J G Oyen
Dec 3, 2016·Therapeutic Advances in Hematology·Markus Ruhnke, Stefan Schwartz
Jun 20, 2018·QJM : Monthly Journal of the Association of Physicians·B Leroy-FreschiniA Imperiale
Feb 23, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Mette Bordinggaard BrøndserudSøren Hess
Sep 5, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Abass AlaviPoul Flemming Høilund-Carlsen
Sep 19, 2017·Current Opinion in Infectious Diseases·Abby DouglasMonica Slavin
Dec 14, 2017·Journal of Paediatrics and Child Health·Shiqi Stacie WangGabrielle M Haeusler
Sep 23, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Abdullah Al-ZaghalAbass Alavi
Jun 9, 2018·European Journal of Nuclear Medicine and Molecular Imaging·A P DouglasM A Slavin
Mar 3, 2017·Nuclear Medicine and Molecular Imaging·Nastassja MullerAlessio Imperiale

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