Use of fertility drugs and risk of endometrial cancer in an Italian case-control study

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Fabio ParazziniC La Vecchia

Abstract

The objective of this study was to analyse time-related aspects of the use of fertility drugs related to the risk of endometrial cancer using data from a case-control study conducted between 1992 and 2006 in Italy. The study included 454 cases (median age, 60 years; range, 18-79) with incident, histologically confirmed endometrial cancer and 908 female controls (median age, 61 years; range 19-79) admitted to the same network of hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. Controls were frequency matched to cases with a 2:1 ratio for age and study centre. Information was collected by trained interviewers using a structured questionnaire. We calculated odds ratios (ORs) and the corresponding 95% confidence intervals (CI) using conditional logistic regression models adjusted for major relevant covariates. The OR of endometrial cancer for ever use of fertility drugs was 3.26 (95% CI, 1.07-9.95). The risk was higher for duration of use 12 months or more (OR=6.10; 95% CI, 0.96-38.6), time since last use 25 years or less before the interview (OR=5.30; 95% CI, 1.12-25.1), and for age at first use less than 30 years (OR=5.14; 95% CI, 1.13-23.4). The association was apparently stronger in ever-gravid (OR=6....Continue Reading

References

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Citations

Nov 5, 2016·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org, UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Mar 30, 2017·The Cochrane Database of Systematic Reviews·Alkistis SkalkidouEleni Petridou
Jun 5, 2018·BioMed Research International·QingAn YuHongChi Jiang
Jun 14, 2019·Frontiers in Endocrinology·Zohre MomenimovahedHamid Salehiniya
Jan 5, 2021·Cancer Causes & Control : CCC·Sonia GuleriaSusanne K Kjær
Feb 16, 2021·Human Reproduction·Jennifer Frances BarcroftSrdjan Saso

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