PMID: 7042370Jan 1, 1981Paper

Use of fixed doses of beta blocking drugs in the treatment of hypertension. Randomised study of atenolol and penbutolol

European Journal of Clinical Pharmacology
L D LameijerD R Chadha

Abstract

Atenolol 100 mg and penbutolol 40 mg given once a day were both effective in controlling moderate hypertension, as judged by a randomised controlled, double-blind trial in 45 patients treated for six weeks. Both drugs significantly reduced the resting supine and erect blood pressures. No serious adverse effects could be attributed to either drug. Bradycardia occurred more frequently with atenolol than with penbutolol. Penbutolol, which possesses intrinsic sympathomimetic activity, may be useful in the treatment of patients in whom some other beta-blocker has failed to bring about adequate control of the blood pressure, despite marked bradycardia.

References

Jan 1, 1979·European Journal of Clinical Pharmacology·G NybergA Vedin
Jan 1, 1977·The Journal of International Medical Research·V H YajnikS H Patel
Oct 1, 1977·British Journal of Clinical Pharmacology·T A JeffersN P Barker
Jul 1, 1979·Journal of Clinical Pharmacology·J L CangianoM Martinez-Maldonado
Apr 24, 1976·British Medical Journal·A P Douglas-Jones, J M Cruickshank
May 1, 1976·Clinical Pharmacology and Therapeutics·M G MyersC T Dollery

Citations

May 1, 1990·Journal of Clinical Pharmacology·William H Frishman, S Covey
Dec 25, 2004·International Journal of Clinical Practice. Supplement·L AlcocerR Dominguez-Henkel
Jun 1, 1989·The American Journal of Cardiology·J A Schoenberger

Related Concepts

Tenormin
Diastolic Blood Pressure
Clinical Trials
Pulse Rate
Hypertensive Disease
Betapressin
Propanolamines
Pulse Taking
Randomization

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.