PMID: 22571192May 11, 2012Paper

Use of Flow Focusing® technology to produce tobramycin-loaded PLGA microparticles for pulmonary drug delivery

Medicinal Chemistry
Lucía Martín-BanderasM Fernández-Arévalo

Abstract

In the present work, a promising formulation of an inhaled powder based on tobramycin-loaded microparticles has been reported. Biodegradable microparticles with controlled diameters in the range of 1-5 μm and narrow size distribution were synthesized by Flow Focusing® technology. Particles production was planned and optimized with the aid of a well-established mathematic model. Close agreements between theoretical an experimental sizes were obtained. To deliver a high payload of tobramycin to the lungs, the influence of surfactant concentration, polymer-drug ratio and initial drug concentration were investigated. For chosen formulations, drug delivery profiles were also studied. In some cases, it was found a controlled drug delivery for more than ten days, which could represent an important advance in the treatment of chronic lung infections. Other particles factors affecting deposit of an aerosol in the lung were also studied, such as surface charge and density.

Citations

Aug 21, 2013·Advanced Drug Delivery Reviews·A M Gañán-CalvoM Flores-Mosquera
Feb 3, 2015·Expert Opinion on Drug Delivery·Mareike Klinger-StrobelOliwia Makarewicz
Jan 10, 2013·International Journal of Pharmaceutics·Lucía Martín-BanderasJosé L Arias

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