Abstract
To assess the efficacy, usefulness, safety, and dosages of flumazenil required when flumazenil is used in the diagnosis of benzodiazepine-induced coma (vs. other drug-induced coma), and to reverse or prevent the recurrence of unconsciousness. A two-phase study: a controlled, randomized, double-blind study followed by a prospective, open study. An 800-bed, teaching, university-affiliated hospital. Unconscious patients (n = 110) suspected of benzodiazepine overdose, graded 2 to 4 on the Matthew and Lawson coma scale, were treated with flumazenil, the specific benzodiazepine receptor antagonist. The first 31 patients were studied in a double-blind fashion, while the rest of the patients were given flumazenil according to an open protocol. INTERVENTIONS; All patients received supplemental oxygen; endotracheal intubation was performed, and synchronized intermittent mandatory ventilation was initiated whenever it was deemed necessary. A peripheral intravenous cannula was inserted, as were indwelling arterial and urinary bladder catheters. Blood pressure, electrocardiogram, respiratory rate, end-tidal CO2, and core temperature were continuously monitored. The first 31 double-blind patients received either intravenous flumazenil (to a ...Continue Reading
References
Mar 1, 1977·Clinical Pharmacology and Therapeutics·D J GreenblattR I Shader
Apr 1, 1977·Clinical Pharmacology and Therapeutics·D J GreenblattR I Shader
Jan 1, 1977·British Medical Journal·C M CastledenC Hallett
Oct 20, 1978·JAMA : the Journal of the American Medical Association·D J GreenblattR I Shader
Jan 14, 1978·British Medical Journal·A T Proudfoot, J Park
Jan 1, 1977·British Medical Journal
Jan 1, 1977·British Medical Journal·C F George, M Castleden
Dec 1, 1992·Critical Care Medicine·A MordelD Ezra
Jan 1, 1991·Intensive Care Medicine·A WeinbroumE Geller
Oct 1, 1991·Acta Anaesthesiologica Scandinavica·J HöjerL L Gustafsson
Jan 1, 1991·European Neurology·E GellerG Scollo-Lavizzari
Dec 8, 1990·BMJ : British Medical Journal·J HöjerL L Gustafsson
Feb 1, 1991·Anesthesia and Analgesia·E GellerH B Miller
Jan 1, 1990·Acta Anaesthesiologica Scandinavica. Supplementum·A Weinbrum, E Geller
Sep 30, 1989·BMJ : British Medical Journal·B MarchantM Nama
Feb 1, 1989·Anaesthesia·B J PollardP Bunting
Jun 24, 1989·BMJ : British Medical Journal·W BurrA Judd
Aug 1, 1989·Journal of Internal Medicine·J HöjerL Gustafsson
Apr 1, 1985·Archives of Internal Medicine·P Hofer, G Scollo-Lavizzari
Oct 1, 1985·Scottish Medical Journal·D G Willox
Jun 1, 1986·Archives of Internal Medicine·P Lheureux, R Askenasi
Sep 1, 1987·Clinical Pharmacology and Therapeutics·G F O'Sullivan, D N Wade
Jan 1, 1988·Resuscitation·E GellerP Sorkine
Sep 1, 1986·British Journal of Anaesthesia·B RicouM Gemperle
Apr 1, 1987·British Journal of Anaesthesia·E AlonG Hossli
Apr 9, 1988·British Medical Journal·B Kirkup
Apr 9, 1988·British Medical Journal·T G ShortD C Galletly
Apr 1, 1988·Anaesthesia·L KnudsenS Jensen
Mar 1, 1988·Human Toxicology·P Lheureux, R Askenasi
Jan 1, 1988·Acta Medica Scandinavica·J Höjer, S Baehrendtz
Jan 1, 1988·Anaesthesia·N P Hirsch
Nov 1, 1987·Journal of Analytical Toxicology·B Heyndrickx
Mar 16, 1985·British Medical Journal·C H Ashton
Nov 7, 1974·The New England Journal of Medicine·D J Greenblatt, R I Shader
Jan 1, 1983·European Neurology·G Scollo-Lavizzari
Jan 1, 1984·Current Medical Research and Opinion·M B BalterE H Uhlenhuth
Jan 1, 1981·Psychopharmacology·M DivollR I Shader
Apr 1, 1993·Critical Care Medicine·E WinklerD Ezra
Nov 1, 1993·Anesthesia and Analgesia·A ForsterD R Morel
Citations
Oct 20, 1999·Clinical Cardiology·T S TsangJ B Seward
Jul 1, 1997·Critical Care Clinics·D D Vernon, M C Gleich
Feb 15, 2000·Journal of Internal Medicine·A Nordin-Johansson, K Asplund
Oct 3, 2000·The Clinical Journal of Pain·A A WeinbroumD Niv
Feb 6, 1999·Critical Care Medicine·R BarnettB A Finegan
Apr 26, 2012·Pediatric Emergency Care·Allyson A KreshakF Lee Cantrell
May 20, 1998·Clinical and Experimental Pharmacology & Physiology·N A Buckley
Nov 30, 2000·Critical Care : the Official Journal of the Critical Care Forum·D Crippen
Jun 9, 2014·The American Journal of Emergency Medicine·Yeon Young KyongKyoung Ho Choi
Aug 21, 2014·Canadian Journal of Physiology and Pharmacology·Martha MullallyJohn T Arnason
Feb 21, 1998·Intensive Care Medicine·A A WeinbroumE Geller
Mar 12, 2003·Chest·Babak MokhlesiThomas C Corbridge
Jun 23, 2015·Basic & Clinical Pharmacology & Toxicology·Elisabeth I PenningaGesche Jürgens
Feb 11, 2003·Chest·Babak MokhlesiThomas C Corbridge
Jul 7, 2012·The Journal of Emergency Medicine·Allyson A KreshakChristian A Tomaszewski
Aug 12, 2008·Forensic Science International : Synergy·M Mahbub Alam MajumderStefan W Toennes
May 20, 2003·Paediatric Anaesthesia·Avi A WeinbroumBernard Belhassen
Nov 7, 2012·British Journal of Clinical Pharmacology·Sean David HoodGary Kenneth Hulse
Jul 22, 1998·The American Journal of Emergency Medicine·A L Weiner, C A McKay
Feb 24, 2001·Emergency Medicine Clinics of North America·T Lemke, R Wang
Jan 9, 2004·Clinics in Chest Medicine·Babak Mokhlesi, Thomas Corbridge
Dec 12, 2001·European Journal of Anaesthesiology·A A WeinbroumR Flaishon
Mar 31, 2015·The Surgical Clinics of North America·Sharon MoranSusan Steinemann
Jan 24, 2009·Journal of Psychopharmacology·S HoodG Hulse
Nov 24, 2004·Human & Experimental Toxicology·Frédéric MarracheMarie Thuong
Jun 30, 2011·Journal of Pharmacy Practice·Simon W LamSeth R Bauer
Sep 2, 2006·Journal of Intensive Care Medicine·David P BettenRichard F Clark
Jul 15, 2017·American Journal of Therapeutics·Rukma Parthvi, Sunil Mehra
Mar 13, 2014·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Philip W MooreJ J Rasimas
Sep 5, 2013·Critical Care Nursing Quarterly·Sruti R Patel
Apr 8, 2020·Critical Care Explorations·Kendra J SchomerTimothy E Albertson
Jun 25, 2004·Journal of Toxicology. Clinical Toxicology·Donna L Seger
Nov 24, 2020·Annals of Intensive Care·Bruno MégarbaneCharles Cerf
Feb 6, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Binila Chacko, John V Peter