Use of fractional CO2 laser decreases the risk of skin cancer development during ultraviolet exposure in hairless mice

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Jiwon GyeSeung-Phil Hong

Abstract

Nonmelanoma skin cancers are caused mainly by prolonged ultraviolet (UV) exposure. There is a growing interest in the prevention of skin cancer and antiaging treatment because of aging of the population. Currently, ablative fractional photothermolysis (FP) laser treatment is actively being performed for facial rejuvenation. The objective of this study was to prove the suppressive effect of CO2 fractional laser (FL) on skin cancer development. Two groups of hairless mice were treated with either CO2 FL or nothing at 3-week intervals during the 20 weeks of UV exposure period. The number of tumors was subsequently counted every 2 weeks over the 30-week period to the termination of the experiment. At 30 weeks, representative tumors were evaluated for tumor type. The authors also determined the messenger RNA (mRNA) expression levels of the matrix metalloproteinase 13 (MMP-13) and Type 1 procollagen. At 30 weeks, the UV- and FL-treated group showed a significantly lower tumor occurrence rate and a more benign progression of tumors than the UV-only treated group. The UV- and FL-treated group presented a higher mRNA level of Type 1 procollagen and a lower level of MMP-13 than the UV-only treated group. The occurrence of UV-induced skin...Continue Reading

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Citations

Jun 9, 2016·Annals of Dermatology·Ji Seok KimSeung Phil Hong
Jan 28, 2018·Scientific Reports·Su Woong YooEuiheon Chung
Mar 6, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jared R JagdeoJeffrey B Travers
Sep 22, 2021·Photobiomodulation, Photomedicine, and Laser Surgery·Aysenur Botsali, Ercan Caliskan

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