Nov 18, 2006

Use of gastroprotective agents in recommended doses in hospitalized patients receiving NSAIDs: a drug utilization study

Pharmacy World & Science : PWS
Viktorija ErdeljicIveta Mercep


In recent years, studies investigated to what extend recommendations for co-prescribing gastroprotective agents in prevention of NSAID-induced gastrointestinal complications are followed in clinical practice. However, only a few studies have also taken into consideration the recommended dose of gastroprotectives prescribed in NSAID-induced ulcer prophylaxis. The aim of our study was to evaluate the prevalence of concomitant use of gastroprotectives with NSAIDs in hospitalized patients, with emphasis on the recommended dose of gastroprotectives for ulcer prophylaxis. This observational, cross-sectional, drug utilization study included all adult patients receiving NSAIDs hospitalized in the Clinical Hospital Center Zagreb on the day of the study. Data on age, sex, comorbidities, indications for NSAID use, type/dose of NSAIDs and gastroprotectives, history of gastrointestinal events, active gastrointestinal symptoms and risk factors were evaluated. Study outcomes were: (1) prevalence of prescription of gastroprotectives among NSAID-users at risk; (2) prevalence of prescription of gastroprotective in recommended dose; (3) association between risk factors and prescription of GPAs. The rates of gastroprotectives prescription were sig...Continue Reading

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Mentioned in this Paper

Cholera Infantum
Analgesics, Anti-Inflammatory
Nonsteroidal Anti-inflammatory Drug [EPC]
Anti-Inflammatory Agents, Non-Steroidal
Hospitalized Patients
Observation - Diagnostic Procedure
Gastrointestinal Symptom
Gastrointestinal Complication

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