Use of gated 13N-NH3 micro-PET to examine left ventricular function in rats

Nuclear Medicine and Biology
Mariusz K SzymanskiRiemer H J A Slart

Abstract

Myocardial perfusion gating techniques offer the possibility of measurement of left ventricular end-systolic (ESV) and end-diastolic volume (EDV) and left ventricular ejection fraction (LVEF) in clinical and preclinical trials. The aim of this study was to evaluate left ventricular volumes (LVV) and LVEF with 13N-NH3 in comparison with the reference 18F-FDG in different rat models. In this study, 18 male Wistar rats, 12 control rats and 6 rats with myocardial infarction (MI) were imaged with micro-PET. The ratswere scanned with gated 13N-NH3 and 18F-FDG sequentially for the assessment of LVV and LVEF. A validated three-dimensional segmentation algorithm was used to calculate LVV and LVEF. Mean LVEF measured with 13N-NH3 was 45.6±8.9 and 75.3±9.4%, mean ESV was 0.40±0.12 and 0.14±0.11 ml, and mean EDVwas 0.53±16 and 0.75±0.18 ml for MI and control rats, respectively. Moderate to good correlations were observed between values of 13N-NH3 and 18F-FDG for calculation of ESV [r=0.80, P<.0001, standard error of estimate (SEE)=0.10], EDV (r=0.63, P=.005, SEE=0.14) and LVEF (r=0.84, P<.0001, SEE=9.5). LVEF measured with 13N-NH3 was significantly lower in MI rats in comparison to measurement with 18F-FDG (45.6±8.9 vs 54.9±9.3 %; P=.04). ...Continue Reading

References

Nov 1, 1996·Circulation·B C GhoP D Verdouw
Dec 23, 1999·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·A T WillemsenA M Paans
Feb 23, 2007·The New England Journal of Medicine·Paolo G Camici, Filippo Crea
Jan 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·René A TioRiemer H J A Slart
Jan 14, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Reza GolestaniRiemer H J A Slart

❮ Previous
Next ❯

Citations

Oct 5, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andrew M HernandezGrant T Gullberg
Sep 26, 2014·The International Journal of Cardiovascular Imaging·Luis E Juárez-OrozcoRiemer H J A Slart
Apr 21, 2017·Frontiers in Medicine·Francesco CiconeJohn O Prior
Jan 16, 2014·Journal of Labelled Compounds & Radiopharmaceuticals·Vanessa Gómez-VallejoJordi Llop
Oct 24, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sazan RasulMarcus Hacker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology
Yohan RobinsonDieter Böning
Clinical Chemistry and Laboratory Medicine : CCLM
Salvatore SotgiaCiriaco Carru
© 2022 Meta ULC. All rights reserved