Use of ginsenoside Rg3-loaded electrospun PLGA fibrous membranes as wound cover induces healing and inhibits hypertrophic scar formation of the skin

Colloids and Surfaces. B, Biointerfaces
Xiaoming SunWenguo Cui

Abstract

Prevention of hypertrophic scar formation of the skin requires a complex treatment process, which mainly includes promoting skin regeneration in an early stage while inhibiting hypertrophic formation in a later stage. Electrospinning PLGA with the three-dimensional micro/nano-fibrous structure and as drugs carrier, could be used as an excellent skin repair scaffold. However, it is difficult to combine the advantage of nanofibrous membranes and drug carriers to achieve early and late treatment. In this study, Ginsenoside-Rg3 (Rg3) loaded hydrophilic poly(D,L-lactide-co-glycolide) (PLGA) electrospun fibrous membranes coated with chitosan (CS) were fabricated by combining electrospinning and pressure-driven permeation (PDP) technology. The PDP method was able to significantly improve the hydrophilicity of electrospun fibrous membranes through surface coating of the hydrophilic fibers with CS, while maintaining the Rg3 releasing rate of PLGA electrospun fibrous membranes. Experimental wounds of animal covered with PDP treated fibrous membranes completely re-epithelialized and healed 3-4 days earlier than the wounds in control groups. Scar elevation index (SEI) measurements and histologic characteristics revealed that Rg3 significan...Continue Reading

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Citations

Mar 2, 2016·Colloids and Surfaces. B, Biointerfaces·Dandan ZhangWenguo Cui
Mar 24, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiaoming SunWenguo Cui
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Wen ZhaoChenrui Li
Feb 28, 2015·Advanced Healthcare Materials·Mohammad NorouziMasoud Soleimani
May 31, 2015·Archives of Dermatological Research·Tae-Gyu LimKi Won Lee
Jan 27, 2015·European Journal of Pharmacology·Kwan Chul TarkMyung Chul Lee
Jan 11, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Kiran Kumar ChereddyVéronique Préat
May 21, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hong HeHai-Ying Gu
Jan 28, 2017·Burns and Trauma·Maedeh RahimnejadWen Zhong
Jun 6, 2017·Drug Development and Industrial Pharmacy·Shaozhi ZhangQiu Yan
Apr 12, 2019·Advanced Healthcare Materials·Tingting XuBo Chi
Mar 14, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Antonios KeirouzNorbert Radacsi
Jun 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hao ChenLianfu Deng
Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roxana GhiulaiCodruţa Şoica
May 28, 2021·International Journal of Pharmaceutics·Essam A TawfikSusan A Barker
Feb 19, 2019·ACS Applied Materials & Interfaces·Yi XiangWenguo Cui

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