Use of gonadotropin-releasing hormone agonist to trigger follicular maturation for in vitro fertilization

The Journal of Clinical Endocrinology and Metabolism
Y GonenR F Casper

Abstract

In spontaneous cycles both LH and FSH are secreted in a surge at midcycle. In in vitro fertilization (IVF) cycles, hCG administration results in elevation of LH-like activity only. The objective of this study was to compare the effectiveness of a single midcycle dose of GnRH agonist with hCG on follicular maturation. Eighteen IVF cycles in 14 women were randomized to receive either 0.5 mg leuprolide acetate or 5000 IU hCG at midcycle. Both groups underwent identical ovarian stimulation and cycle monitoring. On the day of GnRH agonist or hCG administration, estradiol concentrations and the number of follicles 1.5 cm or larger were the same in both groups. Mean serum LH and FSH levels were elevated for 34 h after GnRH agonist administration. In contrast, mean serum hCG levels were elevated for approximately 6 days after the administration of hCG, and serum FSH levels did not change. Mean luteal phase serum estradiol concentrations were lower in the GnRH agonist group than in the hCG group (P less than 0.02). No differences were observed in mean serum progesterone or PRL during the luteal phase or in the length of the luteal phase in the two groups. The mean number of oocytes retrieved and embryo number and quality did not differ ...Continue Reading

Citations

Mar 20, 2012·Cell and Tissue Research·Ky G PohlerMichael F Smith
Feb 26, 2008·Journal of Assisted Reproduction and Genetics·Toshiki MatsuuraOsamu Kato
Jan 13, 2012·Journal of Assisted Reproduction and Genetics·Juan C CastilloPeter Humaidan
Jun 27, 2003·Trends in Endocrinology and Metabolism : TEM·Bart C J M Fauser, Paul Devroey
Jul 18, 2009·Human Reproduction·P HumaidanB C Tarlatzis
Oct 7, 2010·Human Reproduction·P HumaidanB C Tarlatzis
Aug 11, 2011·Human Reproduction·Paul DevroeyChristophe Blockeel
Apr 1, 2011·Human Reproduction Update·P HumaidanUNKNOWN Copenhagen GnRH Agonist Triggering Workshop Group
Nov 1, 1993·British Journal of Obstetrics and Gynaecology·P VandekerckhoveT W Harada
Jun 29, 2010·Reproductive Biology and Endocrinology : RB&E·Alessia NicoliGiovanni B La Sala
Jul 22, 2014·Reproductive Biomedicine Online·Peter Humaidan, Birgit Alsbjerg
Mar 1, 1994·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J BalaschJ A Vanrell
Jun 1, 1995·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M KulikowskiM Szamatowicz
Oct 31, 2015·Systems Biology in Reproductive Medicine·Itai GatClifford L Librach
Jan 31, 2016·Fertility and Sterility·Ernesto BoschDavid Meldrum
Aug 27, 2013·Gynécologie, obstétrique & fertilité·A Guivarc'h-LevêqueP Arvis
Jan 25, 2016·Reproductive Biomedicine Online·Lawrence EngmannPeter Humaidan
Jan 23, 2013·Reproductive Biomedicine Online·Shahar Kol, Peter Humaidan
Jan 23, 2003·Reproductive Biomedicine Online·M H van der GaastB C J M Fauser
Nov 24, 2011·Endocrinology and Metabolism Clinics of North America·Takako ArakiLeonid Poretsky
Apr 27, 2010·Fertility and Sterility·Peter HumaidanEvangelos G Papanikolaou
Dec 16, 2006·Reproductive Biomedicine Online·L EngmannC Benadiva
Feb 2, 2010·Reproductive Biomedicine Online·J C CastilloF Bonilla-Musoles
Aug 22, 2015·Journal of Ovarian Research·Raoul Orvieto
Nov 21, 2015·Journal of Ovarian Research·Stefano PalombaGiovanni Battista La Sala

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.