Use of granulocyte colony-stimulating factor in patients with severe sepsis or septic shock

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Rima A Mohammad

Abstract

The efficacy and safety of granulocyte colony-stimulating factor (G-CSF) in critically ill patients with severe sepsis or septic shock were evaluated. The medical literature was reviewed to identify published trials, case reports, and case series on the use of G-CSF in critically ill patients for treatment of severe sepsis or septic shock. G-CSF has been evaluated as an adjunct to standard care for critically ill patients. Initial studies involving critically ill patients with severe sepsis or septic shock found mortality benefits with G-CSF therapy; however, these findings are limited by factors such as small sample sizes, selection bias, and lack of an appropriate control group. Prospective, randomized, multicenter, double-blind studies failed to confirm the benefits in mortality for patients receiving G-CSF for the treatment of severe sepsis and septic shock. Due to the limitations in the design of the studies that report a mortality benefit and prospective, randomized, multicenter, double-blind studies that report the lack of a mortality benefit, a recommendation to add G-CSF as an adjunctive therapy in critically ill patients with severe sepsis and septic shock cannot be made at this time. The available data, especially th...Continue Reading

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Citations

Dec 23, 2010·Immunotherapy·Anastasia Antonopoulou, Evangelos J Giamarellos-Bourboulis
Oct 2, 2013·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Krishna M Sundar, Mazen Sires
Oct 8, 2013·Critical Care Clinics·Hasan M Al-DorziYaseen M Arabi
Jan 8, 2011·British Journal of Haematology·Jon Cohen, Stephen Drage
Jun 4, 2013·Current Opinion in Immunology·Fabienne VenetGuillaume Monneret
Apr 13, 2019·Journal of Neurosurgery. Pediatrics·Sravanthi KoduriCormac O Maher
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Sep 26, 2019·Seminars in Immunopathology·Asuka Terashima, Hiroshi Takayanagi
May 16, 2021·Seminars in Liver Disease·Cornelius EngelmannThomas Berg

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