Use of HCV-Positive Livers in HCV-Negative Recipients

The American Journal of Gastroenterology
Paul J ThuluvathTalan Zhang

Abstract

There are only limited data on the survival outcomes after transplanting HCV RNA-positive liver into HCV RNA-negative recipients. The objective of our study was to determine whether there were graft and patient survival differences when HCV-negative patients received HCV RNA (nucleic acid amplification testing [NAT] positive)-positive liver grafts. We queried the United Network for Organ Sharing data sets from January 2014 to December 2018, and recipients (N = 24,724) were stratified into 6 groups based on the status of HCV antibody and RNA of recipients and donors. The Cox proportional hazard regression was used to estimate the relationship between groups and 1-year post-LT graft or patient survival. During the study period, 1,358 recipients received NAT-positive liver grafts. Two hundred ten of the recipients were HCV negative. During the same period, 707 HCV antibody-positive but NAT-negative grafts were transplanted into 516 HCV-positive and 191 HCV-negative recipients. There were no differences in survival in HCV-positive recipients whether they received NAT-positive grafts (n = 1,148) or HCV antibody-negative/NAT-negative grafts (n = 6,321). Recipients of grafts from HCV antibody-positive/NAT-negative donors had similar s...Continue Reading

References

Apr 24, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A PrussW H Gerlich
Mar 16, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L M KucirkaD L Segev
May 7, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A SuryaprasadUNKNOWN Organ Transplantation Hepatitis C Investigation Team
May 7, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M G Ison
Jul 28, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M G BowringC M Durand
May 2, 2017·The New England Journal of Medicine·David S GoldbergPeter P Reese
Jul 9, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C E KlingL Sibulesky
Dec 6, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Khurram BariShimul A Shah
Dec 10, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jagpreet ChhatwalRaymond T Chung
May 2, 2018·Annals of Internal Medicine·Christine M DurandDorry L Segev
Jun 26, 2018·Journal of Hepatology·Luca Saverio BelliUNKNOWN all the contributing centers (www.eltr.org) and the European Liver and Intestine Transplant Association (ELITA)
Jul 25, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Michael E de VeraRafael Villicana
Feb 16, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Rhondalyn C McLeanDavid S Goldberg
Apr 5, 2019·The New England Journal of Medicine·Ann E WoolleyUNKNOWN DONATE HCV Trial Team

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Citations

Feb 18, 2021·Current Opinion in Organ Transplantation·Christopher J DanfordDiane Alonso
Jan 21, 2021·World Journal of Surgery·Brian J BoyarskyDorry L Segev

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