PMID: 9648348Jul 2, 1998Paper

Use of hematopoietic stem cells from cord blood for allogenic transplantation in man

Bulletin de l'Académie nationale de médecine
E Gluckman

Abstract

Cells contained in umbilical cord blood collected after birth can be cryopreserved and used for hematopoietic stem cells transplantation in patients with severe hematological disorders. The first success has led to the development of cryopreserved umbilical cord blood banks. More than 500 cord blood transplant have been reported and more than 10,000 cord blood have been stored for use in unrelated and related matched and mismatched transplants. European results show that the number of hematopoietic stem cells present in one cord blood is sufficient to permanently engraft most of the patients. Graft versus host disease is decreased even in unrelated mismatched transplants.

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.