Use of histamine H2 receptor antagonists and outcomes in patients with heart failure: a nationwide population-based cohort study

Clinical Epidemiology
Kasper AdelborgHenrik Toft Sørensen

Abstract

Histamine H2 receptor activation promotes cardiac fibrosis and apoptosis in mice. However, the potential effectiveness of histamine H2 receptor antagonists (H2RAs) in humans with heart failure is largely unknown. We examined the association between H2RA initiation and all-cause mortality among patients with heart failure. Using Danish medical registries, we conducted a nationwide population-based active-comparator cohort study of new users of H2RAs and proton pump inhibitors (PPIs) after first-time hospitalization for heart failure during the period 1995-2014. Hazard ratios (HRs) for all-cause mortality and hospitalization due to worsening of heart failure, adjusting for age, sex, and time between heart failure diagnosis and initiation of PPI or H2RA therapy, index year, comorbidity, cardiac surgery, comedications, and socioeconomic status were computed based on Cox regression analysis. Our analysis included 42,902 PPI initiators (median age 78 years, 46% female) and 3,296 H2RA initiators (median age 76 years, 48% female). Mortality risk was lower among H2RA initiators than PPI initiators after 1 year (26% vs 31%) and 5 years (60% vs 66%). In multivariable analyses, the 1-year HR was 0.80 (95% CI, 0.74-0.86) and the 5-year HR w...Continue Reading

Citations

Jun 26, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ulrike LisewskiTorsten K Roepke
Aug 27, 2021·Drug Discovery Today·Sherin SaheeraRajarajan A Thandavarayan
Oct 9, 2021·Heart Failure Reviews·Scott P Levick

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Methods Mentioned

BETA
coronary artery bypass

Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis