Use of histologic margin evaluation to predict recurrence of cutaneous malignant tumors in dogs and cats after surgical excision

Journal of the American Veterinary Medical Association
Filippo ScarpaGiuliano Bettini

Abstract

To assess the usefulness of histologic evaluation of surgical margins to predict local recurrence of cutaneous malignant tumors in dogs and cats treated by means of surgical excision. Prospective case series. 40 dogs and 20 cats. 60 surgically excised tumors (20 soft tissue sarcomas [STSs], 20 mast cell tumors [MCTs], and 20 carcinomas) were examined histologically. Margins were classified as clean, close, or infiltrated; histologic grade was assessed in STSs and MCTs. Recurrence rates and recurrence-free intervals (RFIs) during a 24-month follow-up period were recorded, and method accuracy was calculated. Surgical margins were clean in 29 of 60 (48%) tumors, close in 11 (18%), and infiltrated in 20 (33%). Tumors recurred in 27 of 60 (45%) animals, with a mean ± SD RFI of 229 ± 173 days. Recurrence rates for animals that had tumors with infiltrated (16/20) or close (8/11) margins were significantly higher than recurrence rate for animals that had tumors with clean margins (3/29). Margin classification was a significant predictor of RFI. Accuracy of the method to predict recurrence was 94% for carcinomas, 87% for STSs, and 76% for MCTs. Histologic assessment of margin status was useful for predicting local recurrence of cutaneou...Continue Reading

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Citations

Nov 1, 2013·Journal of the American Veterinary Medical Association·Kathryn M PratschkeCatherine G Lamm
Jan 1, 2014·Journal of the American Veterinary Medical Association·Cassandra Y PrpichCharles A Kuntz
Nov 10, 2015·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Simona CanceddaCarla Rohrer Bley
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Jan 27, 2019·Veterinary and Comparative Oncology·Jennifer L WillcoxKatherine A Skorupski
Nov 22, 2019·Veterinary and Comparative Oncology·Antonella BorgattiJessica Lawrence
Sep 20, 2019·Journal of Veterinary Dentistry·Deborah L HodessonCynthia M Bell
Jun 21, 2020·Veterinary and Comparative Oncology·Carolina FabeloStephen A Boppart
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Mar 27, 2021·Veterinary Pathology·Giancarlo AvallonePaola Roccabianca

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