Use of histone deacetylase 8 (HDAC8), a new marker of smooth muscle differentiation, in the classification of mesenchymal tumors of the uterus

The American Journal of Surgical Pathology
Laurence de LevalEsther Oliva

Abstract

Uterine smooth muscle tumors (SMTs) are usually recognized on the basis of their routine morphologic features; however, their distinction from endometrial stromal tumors (ESTs), the second most common mesenchymal tumor of the uterus, is sometimes problematic. Histone deacetylases (HDACs) were originally identified as nuclear enzymes regulating histone acetylation. We have recently shown that in normal human tissues, HDAC8 is exclusively expressed in the cytoplasm of cells showing smooth muscle differentiation. In this study, we examined HDAC8 expression in SMTs and ESTs of the uterus to determine whether HDAC8 may be a useful diagnostic tool in the classification of problematic uterine mesenchymal tumors. HDAC8 immunohistochemical staining was performed in 15 leiomyomas (LMs), 9 highly cellular leiomyomas (HCLs), 8 epithelioid SMTs, 13 leiomyosarcomas (LMSs), and 17 ESTs, including 3 with sex-cord differentiation and 5 with smooth muscle differentiation. All tumors were also stained for other smooth muscle markers (desmin, h-caldesmon, smooth muscle actin [SMA], smooth muscle myosin heavy chain) and for CD10. All LMs had moderate to strong expression of all smooth muscle markers. HDAC8 was detected in 8 of 9 HCLs and in all epi...Continue Reading

Citations

Nov 18, 2015·Sarcoma·Tine CuppensFrédéric Amant
Mar 23, 2011·Human Pathology·Sarah Chiang, Esther Oliva
Dec 24, 2008·Cancer Letters·Wilko Weichert
Aug 31, 2016·Future Medicinal Chemistry·Alokta ChakrabartiManfred Jung
Dec 18, 2012·Histopathology·Sarah Chiang, Esther Oliva
Oct 27, 2009·Gynecologic Oncology·Emanuela D'Angelo, Jaime Prat
Jan 18, 2015·Journal of Clinical Pathology·Rola H Ali, Marjan Rouzbahman
Sep 25, 2018·Journal of Cellular Physiology·Luca FerrariAnna Pistocchi
Dec 3, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jianfang LiangHuixia Zheng
Feb 25, 2010·Advances in Anatomic Pathology·Ivy Chew, Esther Oliva
Nov 19, 2010·The American Journal of Surgical Pathology·Laurence de LevalEsther Oliva
Oct 10, 2014·Advances in Anatomic Pathology·Christopher M J Conklin, Teri A Longacre
Jul 18, 2020·Genes, Chromosomes & Cancer·Anjelica HodgsonGulisa Turashvili
Oct 2, 2014·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Roseann I WuEsther Oliva
Sep 16, 2008·Biomaterials·Andrew S Rowlands, Justin J Cooper-White

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