Use of hormone therapies in disseminated carcinomatosis of the bone marrow associated with hormone receptor-positive breast cancer

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Takayo OtaMasahiro Fukuoka

Abstract

Disseminated carcinomatosis of the bone marrow (DCBM) is diffusely invasive bone metastasis resulting from solid tumors. DCBM is often associated with disseminated intravascular coagulation (DIC) or hemolytic anemia. Generally, DCBM treatment includes cytotoxic chemotherapy for underlying solid tumors and management of hematological conditions if present. We report a case of DCBM accompanied with DIC in hormone receptor-positive breast cancer. Due to her life-threatening condition, we used hormone therapies, not cytotoxic chemotherapies, to treat her DCBM. With zoledronic acid, her DIC and general condition gradually improved and eventually she could return to her daily life. If DCBM occurs in hormone receptor-positive breast cancer, hormone therapy can be one of the treatment choices.

References

Apr 16, 2004·The New England Journal of Medicine·G David Roodman
Feb 26, 2009·Cancer·Lakshmi NayakFabio M Iwamoto
May 20, 2011·Nature Reviews. Cancer·Katherine N WeilbaecherLaurie K McCauley

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